多功能稀土配合物光-磁纳米探针构筑及多模式成像和药物控释研究

项目名称： 多功能稀土配合物光-磁纳米探针构筑及多模式成像和药物控释研究

项目编号： No.21471071

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 数理科学和化学

项目作者： 唐瑜

作者单位： 兰州大学

项目金额： 90万元

中文摘要： 本项目在已有成果基础上，以具有核-壳结构的磁性纳米颗粒@有机改性介孔二氧化硅纳米粒子为基质，利用超分子作用和配体交换反应在壳层孔道里负载大环及多足体稀土发光配合物和抗癌药物（阿霉素、紫杉醇或喜树碱等），并在纳米粒子表面包覆功能高分子或生物大分子，构筑具有磁靶向性和刺激响应药物缓释功能的稀土配合物光-磁纳米探针；实现基于稀土配合物的荧光成像和X-射线计算机断层成像、磁性核的磁共振成像和高分辨透射电镜成像等多模式成像功能，并研究各成像模式间的协同效应；利用稀土离子的配位内界可调进行药物输送，并以其荧光信号表达监测药物释放过程；利用电镜成像进行药物示踪和作用机理研究；探索此类多功能稀土配合物纳米探针在癌症诊断和治疗等方面的应用。总结所获新知识及有关规律，为新型稀土配合物多功能纳米探针的设计应用提供重要理论基础。预期可发表高质量学术论文16-20篇，有关成果申请专利，培养博、硕士研究生6-8名。

中文关键词： 稀土配合物；多功能纳米探针；构筑；多模式成像；药物控释

英文摘要： On the basis of our previous researches, we plan to design and fabricate multifunctional rare-earth complexes optical-magnetic nanoprobes with core-shell structures possessing magnetic targeting and stimuli response drug slow-release functions, using magnetic nanoparticles @ organic modified mesoporous silica as matrices, loading the luminescent rare-earth complexes with macrocyclic ligands or podands and anti-cancer drugs (doxorubicin, paclitaxel or camptothecin, etc.) by means of supramolecular interactions and ligand exchange reactions in the shell channel, wrapping the nanoparticles by functional polymers or biological macromolecules. The nanoprobes can realize the fluorescence imaging and X-ray computed tomography (CT) imaging based on the rare-earth complexes, magnetic resonance imaging (MRI) and high resolution transmission electron microscopy (TEM) imaging based on the magnetic nuclei, and the synergy effects between different imaging modes are also planned to investigate. The drug delivery is expected to be implemented by taking advantage of the adjustable coordination sphere of rare-earth ions, and the drug release process can be monitored by the fluorescent signal of the rare-earth complexes expressing. We can also trace the drug and investigate the mechanism by electron microscopy imaging. Thus the applications of such multifunctional rare-earth complexes nanoprobes in cancer diagnosis and treatment are studied. Summarizing the new knowledge and relational rule, we will provide useful informations and academic foundations to the design and application of multifunctional rare-earth complexes nanoprobes. And we expect that sixteen to twenty top-quality papers will be published, some patents can be applied by the relative researches, and six to eight graduate students will be brought up by the project implement.

英文关键词： Rare-earth complexes;Multifunctional Nanoprobe;Fabrication;Multimodal imaging;Drug controlled release