新型有机污染物三-(2,3-二溴丙基）异氰脲酸酯(TBC)的内分泌干扰效应和生殖毒性研究

项目名称： 新型有机污染物三-(2,3-二溴丙基）异氰脲酸酯(TBC)的内分泌干扰效应和生殖毒性研究

项目编号： No.21277062

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 环境科学、安全科学

项目作者： 梁勇

作者单位： 江汉大学

项目金额： 80万元

中文摘要： 杂环溴化阻燃剂- - 三-(2,3-二溴丙基）异氰脲酸酯（TBC）是溴代联苯醚类、四溴双酚A等多种常规溴化阻燃剂的替代产品，在国内已逐渐批量生产及应用，但它最近被证明是一种具有环境持久性的新型有机污染物，其潜在的环境危害和生态风险值得关注。本项目重点研究TBC抑制斑马鱼体内卵黄蛋白原合成、阻碍成鱼性腺发育的作用位点及途径，通过结合利用多种内分泌干扰物离体、活体生物测试模型，并计算TBC与雌激素受体的定量构效关系，以揭示TBC产生内分泌干扰效应的分子致毒机制；同时选择斑马鱼作为模式动物，进一步研究环境浓度下TBC长期低剂量暴露对斑马鱼生长、发育、繁殖及子代的毒性效应，着重探讨TBC是否通过干扰正常内分泌系统功能造成潜在生殖毒性及其具体的作用途径，最终为准确评估TBC这种新型有机污染物的生态风险和环境健康效应，并为溴化阻燃剂及其替代产品的生产和应用提供科学依据。

中文关键词： 三-（2;3）二溴丙基异氰脲酸酯（TBC）；肺损伤；抗雌激素效应；内分泌干扰效应；

英文摘要： Heterocyclic brominated flame retardant tris-(2,3-dibromopropyl) isocyanurate(TBC) is the substitute of regular brominated flame retardants such as polybrominated diphenyl ethers(PBDEs) and tetrabromobisphenol A (TBBPA). It has been batch produced and used domestically. However, TBC is recently proven to be a new environmental persistent organic pollutant, and its potential environmental effects and ecological risk should be taken seriously. Our research focuses on the action sites and pathways though which TBC suppresses hepatic vitellogenin synthesis and hinders gonad development in adult zebrafish（Danio rerio）. By utilizing different in vitro and in vivo bioassay models of endocrine disrupting chemicals (EDCs) and calculating the quantitative structure activity relationship of TBC and estrogen receptor, the molecular mechanism of endocrine toxic effects caused by TBC can be revealed. Meanwhile, zebrafish will be exposed to low-doses of TBC according to environmental concentrations for a full lifetime, in order to study TBC's toxicity effects on growth, development, reproduction and offspring. Furthermore, whether TBC could cause reproductive toxicity through disrupting the functions of endocrine system and the precise mechanism will be discussed. These results can be provided as scientific evidences for evalu

英文关键词： tris(2;3-dibromopropyl) isocyanurate (TBC)；lung injury；anti-estrogenic effect；endocrine disrupting effect；