With rapid transmission, the coronavirus disease 2019 (COVID-19) has led to over 2 million deaths worldwide, posing significant societal challenges. Understanding the spatial patterns of patient visits and detecting the local spreading events are crucial to controlling disease outbreaks. We analyze highly detailed COVID-19 contact tracing data collected from Seoul, which provides a unique opportunity to understand the mechanism of patient visit occurrence. Analyzing contact tracing data is challenging because patient visits show strong clustering patterns while clusters of events may have complex interaction behavior. To account for such behaviors, we develop a novel interaction Neyman-Scott process that regards the observed patient visit events as offsprings generated from a parent spreading event. Inference for such models is complicated since the likelihood involves intractable normalizing functions. To address this issue, we embed an auxiliary variable algorithm into our Markov chain Monte Carlo. We fit our model to several simulated and real data examples under different outbreak scenarios and show that our method can describe spatial patterns of patient visits well. We also provide visualization tools that can inform public health interventions for infectious diseases such as social distancing.
翻译:通过快速传播,2019年科罗纳病毒(COVID-19)导致全世界超过200万人死亡,这给社会带来了巨大的挑战。了解病人访问的空间模式和检测局部传播事件对于控制疾病爆发至关重要。我们分析了从首尔收集的非常详细的COVID-19接触追踪数据,这为了解病人访问的发生机制提供了一个独特的机会。分析接触追踪数据具有挑战性,因为病人访问显示出强大的集群模式,而事件组可能具有复杂的互动行为。为了解释这些行为,我们开发了一个新型的互动Neyman-Scott进程,将观察到的病人访问事件视为由父母传播事件产生的后代。这种模型的推断很复杂,因为其可能性涉及难以调和的正常功能。为了解决这一问题,我们将一个辅助变量算法嵌入我们的Markov连锁Monte Carlo。我们的模式适用于不同爆发情景下的若干模拟和真实的数据实例,并表明我们的方法可以很好地描述病人访问的空间模式。我们还提供了可视化工具,可以告知传染病的公共卫生干预措施,例如社会动荡。