Structure-based drug design powered by deep generative models have attracted increasing research interest in recent years. Language models have demonstrated a robust capacity for generating valid molecules in 2D structures, while methods based on geometric deep learning can directly produce molecules with accurate 3D coordinates. Inspired by both methods, this article proposes a pocket-based 3D molecule generation method that leverages the language model with the ability to generate 3D coordinates. High quality protein-ligand complex data are insufficient; hence, a perturbation and restoration pre-training task is designed that can utilize vast amounts of small-molecule data. A new molecular representation, a fragment-based SMILES with local and global coordinates, is also presented, enabling the language model to learn molecular topological structures and spatial position information effectively. Ultimately, CrossDocked and DUD-E dataset is employed for evaluation and additional metrics are introduced. This method achieves state-of-the-art performance in nearly all metrics, notably in terms of binding patterns, drug-like properties, rational conformations, and inference speed. Our model is available as an online service to academic users via sw3dmg.stonewise.cn
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