The major histocompatibility complex (MHC) molecules, which bind peptides for presentation on the cell surface, play an important role in cell-mediated immunity. In light of developing databases and technologies over the years, significant progress has been made in research on peptide binding affinity calculation. Several in techniques have been developed to predict peptide binding to MHC class I. Most of the research on MHC Class I due to its nature brings better performance and more. Considering the use of different methods and different technologies, and the approach of similar methods on different proteins, a classification was created according to the binding affinity of protein peptides.
翻译:主要的直系兼容性综合体(MHC)分子(MHC)在细胞表面的演示中结合了peptides,在细胞中间免疫中发挥了重要作用;鉴于多年来开发的数据库和技术,在对peptide捆绑性近亲关系计算的研究方面取得了显著进展;在预测peptide与MHCI级的紧凑性方面,开发了几种技术。由于MHCI类的大部分研究的性质,其性能更好,效果更多。考虑到不同方法和不同技术的使用,以及不同蛋白质的类似方法的采用,根据蛋白质粘合性对蛋白质进行了分类。