基于聚偏氟乙烯中空纤维为基体的小口径人工血管的可控制备及抗凝血表面构筑

项目名称： 基于聚偏氟乙烯中空纤维为基体的小口径人工血管的可控制备及抗凝血表面构筑

项目编号： No.51203020

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 有机高分子材料学科

项目作者： 孙俊芬

作者单位： 东华大学

项目金额： 25万元

中文摘要： 目前的小口径人工血管在理化性能和生物力学特性方面难以与人体自身血管相匹配，均具有远期通畅率不足的缺点，限制了它的临床应用。本研究采用具有生物相容性的聚偏氟乙烯（PVDF）为基材，利用干喷湿纺法一次成型纺制PVDF中空纤维小口径人工血管，通过调控PVDF中空纤维血管形成工艺条件，研究PVDF中空纤维血管成型过程中多级凝聚态结构和微孔结构的形成机理及其与宏观分离性能和宏观力学性能的关系，揭示形成中空纤维血管凝聚态结构和微孔结构的演变规律并建立调控方法。利用低温等离子体处理技术在中空纤维血管表面引入亲水基团，接枝生物大分子，固定抗凝素和生物活性物质，研究抗凝血表面改性过程中，表面微观结构和官能团的演变行为和规律对接枝生物大分子、固定抗凝素和生物活性物质的影响，以及中空纤维血管抗凝血表面修饰规律。构建动物实验模型，考察中空纤维血管的性能。该研究为小口径人工血管的选材、成型、抗凝血表面设计提供新思路

中文关键词： 聚偏氟乙烯（PVDF）；中空纤维膜；小口径人工血管；等离子体处理；表面改性

英文摘要： At present, small diameter artificial blood vessel in mechanics properties and biocompatibility is not matched with blood vessel in body. Its clinic application is limited because of its weakness about longtime patency rate. In this research, poly (vinylidene fluoride) (PVDF) hollow fiber spun by dry-wet spinning is used as the matrix of artificial blood vessels. The formation mechanism of PVDF hollow fiber vessel microstructure and the relationship between the formation mechanism and filtration property and mechanic property are studied, which indicate the formation rule of hollow fiber vessel microstructure and helps to establish preparing method. Moreover, plasma treatment is used to treat the surfaces of PVDF hollow fiber vessel and some hydrophilic groups (-COOH、-OH、-NH2,etc ) are introduced onto the surfaces of PVDF hollow fiber vessel and some biomaterials and antiagglutinin are fixed on the surfaces of hollow fiber vessel. The effects of evolution rules about surface microstructure and groups on the method of fixing biomaterials and antiagglutinin, and anticogulation modifying rules of hollow fiver vessel, are studied during the modifying process of hollow fiber vessel surfaces. The animal testing model is built and the properties of hollow fiber vessel are studied in this research. This research provide

英文关键词： poly (vinylidene fluoride) (PVDF)；hollow fiber membrane；small diameter artificial blood vessel；plasma treatment；suface modification