磁性纳米生物材料的绿色合成与性能研究

项目名称： 磁性纳米生物材料的绿色合成与性能研究

项目编号： No.20871001

项目类型： 面上项目

立项/批准年度： 2009

项目学科： 金属学与金属工艺

项目作者： 沈玉华

作者单位： 安徽大学

项目金额： 36万元

中文摘要： 本项目以绿色化学和仿生合成的基本原理为指导，直接利用天然绿色植物以及具有生物相容性的生物分子如维生素、氨基酸和葡萄糖等，原位合成了生物分子包裹、修饰或复合的磁性Fe3O4等纳米生物材料。研究了不同活体组织的结构、生物分子和反应物的浓度、溶液pH值、过饱和度、陈化时间等参数对合成的磁性纳米生物材料的微观结构、聚集形态及磁性能的影响；分析了活体组织细胞、生物分子与磁性纳米材料界面间的相互作用和调控磁性纳米材料成核、生长的机理；在此基础上，探索制备了核壳、复合及负载生物功能分子（如纤维素酶等）或药物分子（如Au等）的复杂结构磁性纳米材料，并初步探讨其在生物医学、环境有机污染物催化降解等方面的应用。该项研究对揭示Fe3O4等磁性矿物在生物体内的矿化机制、设计和仿生合成新型医用、环境净化纳米材料、拓展磁性纳米生物材料的应用范围，促进纳米材料科学的发展等具有重要的意义。? ?

中文关键词： 磁性纳米材料；生物材料；绿色合成；仿生合成；性能

英文摘要： The magnetic nano-biomaterials such as Fe3O4 modified，encapsulated or composited by（or with）biomolecules have been in-situ prepared with the principle of biomimetic synthesis and green chemistry using natural green plants the vitamins, amino acid and saccharides,etc. The effect of different frameworks of living organizations, concentrations of biomolecules and reactants, pH values and supersaturation of the solution, and even reaction time on the microstructure, distribution of the aggregates and magnetic properties of the prepared nanoparticles have been also studied. The interactions between the living cells, biomolecules and the magnetic nanoparticles at the interface, as well as the nucleation and growth mechanism of the nanocrystal induced by the biomolecules have been also analyzed.On the above base, the magnetic nanomaterials with complex structure,such as core-shell, compositing and loading medicine or the functional biomolecules (e.g. cellulase etc.), were synthesized as well. Farther the application of the complex nanomaterials in the fields of targeting drug delivery system and photocatalytic degradation of organic contaminant in environment was investaged. Therefore, this project is very significant to explore mineralization mechanism of biomineral(Fe3O4 etc.) in organism,design and biomimetic synthesize new kinds of medical care and cleaning environment nanomaterials,expand the application of magnetic nanobiomaterials and even promote development of manoscience.

英文关键词： Magnetic nanomaterial; Biomaterial; Green Synthesis; Biomimetic synthesis; Property