成瘾相关的学习记忆与普通的学习记忆有何不同

项目名称： 成瘾相关的学习记忆与普通的学习记忆有何不同

项目编号： No.30870825

项目类型： 面上项目

立项/批准年度： 2009

项目学科： 金属学与金属工艺

项目作者： 马原野

作者单位： 中国科学院昆明动物研究所

项目金额： 35万元

中文摘要： 我们的研究清楚地表明了成瘾的学习记忆和普通的学习记忆似乎有着某些不同的脑机制。一般能影响普通学习记忆的手段和因子不但不损伤成瘾相关的学习记忆，相反地，好像是促进了成瘾相关的学习记忆。因此我们已采用比较的方法，借助条件性位置偏好（CPP）及脑成像等手段来探讨普通的学习记忆和成瘾的学习记忆两者间的异同。我们的研究结果表明成瘾相关的学习记忆与普通的学习记忆之间存在差异。我们的研究结果可能会对现在的学习记忆概念和理论有一定的补充和完善，并对学习记忆的一般概念和理论带来新的认识。

中文关键词： 学习记忆；药物成瘾；条件性位置偏好；脑成像

英文摘要： We found that there are some differences in the brain mechanism between the addictive memory and normal memory. Our current results showed that those influence normal learning and memory, including blocking cholinergical system by scopolamine, inhibiting protein synthesis and electric shock after conditioning of CPP (conditioned place preference) failed to impair (even has reverse effects on ) the learning and memory associated with addiction. Thus, we combined the behavioral tests with brain image techniques including PET and fMRI, to compare the similarities and differences between normal learning and memory with the addiction-related learning and memory. Our study demonstrates that addiction-related learning and memory seems to have some different brain mechanisms with normal learning and memory. The factors that can affect the normal learning and memory don’ affect the addiction-related learning and memory, to the contrary, these factors seems to be the promotion of addiction-related learning and memory. Our findings might improve the general concepts and theories of memory and learning.

英文关键词： learning & memory；drug addiction;conditioned place preference;brain image