基于实时fMRI解码与脑网络建模的听觉信息认知加工机理研究

项目名称： 基于实时fMRI解码与脑网络建模的听觉信息认知加工机理研究

项目编号： No.61503278

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 自动化技术、计算机技术

项目作者： 张高燕

作者单位： 天津大学

项目金额： 22万元

中文摘要： 探索人类听觉信息认知加工机理不仅有利于揭示大脑听觉功能的奥秘,而且有助于中枢系统功能损伤引起的听觉障碍患者的诊断与治疗。本项目将从信息解码的角度研究听觉信息加工过程的皮层表征，构建人脑听觉信息加工的网络模型。研究中拟运用实时功能磁共振成像(real time fMRI)技术在线记录听觉认知脑活动的动态变化，并结合多变量模式分析方法解码听觉内容和方位信息加工的脑区激活模式、脑区连接模式并计算其动态变化，使用动态因果网络分析方法建立脑活动与听觉刺激之间时空映射的网络模型。本项目主要通过实时观测分析技术、认知解码方法和网络建模思想，揭示人脑听觉信息认知加工的神经机理，促进对听觉信息加工理论的理解，以期用于分析听觉障碍的起因及听觉功能恢复的可能途径，同时也为计算机实现人类听觉的模拟提供一定的理论借鉴。

中文关键词： 神经信息解码；认知功能的脑网络表征；实时功能磁共振成像；听觉信息加工；因果网络建模

英文摘要： Exploring the cognitive processing mechanism for auditory information not only benefits the understanding of the brain’s auditory function, but also helps the diagnosis and treatment of auditory disorders induced by the impairment of central nervous system. This project aims to study the cortical representations of auditory information processing from the view of information decoding, and construct a network model of auditory information processing in the human brain. This study intends to employ the real time functional magnetic imaging (real time fMRI) technology to record the dynamic brain activities involved in auditory cognition online, and the multi-variate pattern analysis method to analyze the brain activation pattern and connectivity pattern underlie the auditory object and spatial location processing, as well as the dynamic changes of these patterns, and then construct the network model of temporal-spatial mapping between the brain activities and the auditory stimuli by using the dynamic causal network analysis. This study uses the real time scanning technology, cognitive decoding method and network modeling theory to reveal the neural mechanism underlie auditory information processing, promoting the understanding of auditory information processing theory, so as to apply it to the cause analysis of auditory disorders, and the search of possible approach for recovering the normal auditory function, meanwhile, this study also provides some theoretical reference for the computer simulation of human auditory system.

英文关键词： neural information decoding;brain network representation for cognitive function;real time fMRI;auditory information processing;causal network modeling