碳纳米材料基于光响应及自身光热效应的可控药物释放方面的研究

项目名称： 碳纳米材料基于光响应及自身光热效应的可控药物释放方面的研究

项目编号： No.21301037

项目类型： 青年科学基金项目

立项/批准年度： 2014

项目学科： 数理科学和化学

项目作者： 徐建勋

作者单位： 国家纳米科学中心

项目金额： 25万元

中文摘要： 药物的可控释放是当今药物载体研究领域非常重要的一个方面。当前研究主要利用病变组织有别于正常组织的微环境来实现药物在病变组织的快速释放。但是，由于正常组织与病变组织的差别通常并不大，导致药物载体在病变组织处的药物释放增强效果并不明显；另一方面，由于缺乏良好的控制药物释放的开关功能，许多药物载体在到达病变组织之前也会释放出一定量的药物引起毒副作用。 本申请提出在碳纳米管或碳纳米角上的纳米小孔处修饰上在光照下发生可逆二聚反应的分子作为控制药物释放的类似"双开门"的纳米开关。在到达病变组织之前，封闭的纳米小孔防止药物分子的泄漏；而到达病变组织之后，在外界光照以及光照下碳纳米材料自身发热的协同效应下，二聚体分解，开关分子打开，引起药物迅速释放。本申请通过结合开关分子和碳纳米材料载体的优异性能，获得对外界刺激具有良好开关响应的可控药物释放体系；有望为药物的可控释放研究提供新的思路和一些有意义的结果。

中文关键词： 碳纳米材料；功能化探针；可控释放；；

英文摘要： In current studies on drug delivery, it is of great importance to achieve the release of drugs at both a controlled rate and a controlled location. Previous researches were mainly based on the differences between normal and diseased tissues, including different tissue temperature, different pH value, etc. However, these differences are usually quite small. And some diseased tissues mimic the micro-environments of normal tissues. These result in that the drug release rate cannot be enhanced remarkably in diseased areas. In addition, due to the lack of an effective closing valve, there is still a drug leakage problem for currently widely-used polymeric drug delivery systems. Herein, we propose to anchor some smart molecules at the edge of the nano-sized holes in nano-carbon materials, i.e. carbon nanotubes and carbon nanohorns. The smart molecules to be used are those photo-sensitive molecules, such as coumarin derivatives, which undergo reversible dimerization under light irradiation. These molecules function as nano-valves of the holes in nano-carbon materials. Before reaching the diseased area, the nano-valves are closed and the drugs are well protected inside nano-carbon materials. Upon arrival, the nano-valves open under the stimuli of the light irradiation and the high temperature caused by the photo-thermal

英文关键词： carbon nanomaterials；functional probe；controlled release；；