基于单分散氧化石墨烯药物控释胶囊的构建与特性研究

项目名称： 基于单分散氧化石墨烯药物控释胶囊的构建与特性研究

项目编号： No.21273135

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 数理科学和化学

项目作者： 张人杰

作者单位： 山东大学

项目金额： 80万元

中文摘要： 薄层氧化石墨烯(graphene oxide, GO) 微纳米片具有仅几个碳原子层厚的平面结构，可通过π-π电子堆积等作用吸附装载疏水药物，GO表面电荷的斥力使GO微纳米片彼此分离，提高其负载的疏水药物的水溶性。然而相对于其它微纳米粒子而言，GO在载药及药物控释方面是否具有独特优异性能是亟待解决的关键科学问题。本项目将制备3-6种2μm-50nm范围内的单分散GO，分别在单分散GO和多分散GO表面吸附疏水药物后作为内核，通过层层自组装包覆不同取代基的壳聚糖/海藻酸钠生物大分子壳层和纳米金壳层，得到含GO-药物的生物兼容胶囊；通过纳米金吸收近红外光发热诱导生物大分子构象变化提高壁层通透性，实现药物的远程控释；比较研究近红外光远程控释药物与温度或盐浓度控释药物动力学的异同；在内核中以其它单分散微纳米粒子取代单分散GO组装生物兼容胶囊，比较研究单分散GO在载药、药物协同作用及控释方面的特性。

中文关键词： 氧化石墨烯；药物载体；控释；Pt催化剂抗毒；二氧化锰

英文摘要： Thin layer graphene oxide (GO) micro-/nano-sheets have planar structures with the thickness of a few carbon atoms, capable of loading hydrophobic drugs through interactions including π-π electrons stacking. The repulsion of surface charges on GO sheets separates them from each other, thereby increasing the solubility of hydrophobic drugs. However, compared to other micro-/nano-particles, a key scientific issue is whether GO sheets have distinguished characteristics for drug loading and controlled release. In this project, 3-6 kinds of monodisperse GO sheets in the range of 2 μm - 50 nm will be prepared for hydrophobic drugs loading, and used as cores to assemble different substituents of chitosan / sodium alginate biological macromolecules, as well as gold nanoparticles in shells, and thus biocompatible capsules will be fabricated. Irradiated by near infrared light, the gold nanoparticles will heat biological macromolecules, whose conformation will consequently be changed; thus the permeability of the capsules will be increased, enabling the remote control of the drug release. A comparative study between near-infrared light, temperature and salinity on the dynamics of controlled drug release will also be carried out. Other monodisperse micro-/nano-particles will also be selected instead of the GO sheets in cores

英文关键词： graphene oxide；drug carrier；controlled release；toxicity-resistance of Pt catalysts；MnO2