颈内动脉狭窄致Willis环代偿功能失效的血流动力学机理研究

项目名称： 颈内动脉狭窄致Willis环代偿功能失效的血流动力学机理研究

项目编号： No.11302019

项目类型： 青年科学基金项目

立项/批准年度： 2014

项目学科： 数理科学和化学

项目作者： 张弛

作者单位： 北京航空航天大学

项目金额： 26万元

中文摘要： Willis环是预防脑缺血的重要生理结构。颈内动脉狭窄的病人中，脑缺血导致的脑卒中发病率很高，说明Willis环的代偿功能在部分病人中失效了。研究其失效的机理对于预防脑卒中具有重要意义。推测其原因有：颈内动脉狭窄病人与正常人的Willis环结构及功能变异性存在差异；Willis环代偿功能随狭窄的发展而减弱；Willis环的侧支循环可能会影响颈内动脉的血流动力学，加剧狭窄的发展。本项目针对上述可能原因开展研究：基于临床Willis环影像，评估颈内动脉狭窄病人与正常人的Willis环结构及功能变异性的差异；用Willis环的集中参数模型评价其代偿功能在狭窄发展过程中的变化；建立Willis环集中参数和颈内动脉三维血流动力学耦合的多尺度模型，研究Willis环侧支循环对狭窄发展的影响。本项目的创新之处在于研究了Willis环代偿功能与颈内动脉狭窄发展的相互影响，为控制狭窄的发展提供新的思路。

中文关键词： Willis环；颈内动脉狭窄；代偿功能；多尺度模型；脑卒中

英文摘要： Willis circle is an important physical structure for preventing cerebral ischemia. However, in patients with internal carotid artery (ICA) stenosis, the incidence of stroke caused by cerebral ischemia is high, indicating the compensatory ability of Willis circle is invalidated in part of these patients. The mechanism study on the invalidation of compensatory ability has important implications for preventing the occurence of stroke. The reasons are inferred as follow: the variability of structure and compensatory ability of Willis circle may differ between the normal and patients with ICA stenosis; the compensatory ability is weakened with the development of ICA stenosis; the collateral circulation of Willis circle may influence the hemodynamics in ICA, and further intensify the stenosis. Aiming at the three possible reasons, the study includes: 1. based on clinical image of Willis circle, assessing the variability of the structure and compensatory ability of Willis circle between the normal and patients with ICA stenosis; 2. evaluating the variation of compensatory ability with lumped parameter model of Willis circle during the development process of ICA stenosis; 3. building the multi-scale model with the coupling between lumped parameter of Willis circle and 3D hemodynamics in ICA, to study the effect of coll

英文关键词： circle of Willis；internal carotid artery stenosis；compensatory ability；multi-scale model；stroke