面向膀胱功能修复的分体植入式神经调控微系统与相关机制研究

项目名称： 面向膀胱功能修复的分体植入式神经调控微系统与相关机制研究

项目编号： No.61474107

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 无线电电子学、电信技术

项目作者： 张旭

作者单位： 中国科学院半导体研究所

项目金额： 90万元

中文摘要： 本课题针对脊髓损伤后引起的排尿功能障碍治疗，以及预防由此引发的泌尿系统乃至全身的致命性并发症，研究适用于微创手术的基于脊髓神经记录-骶神经刺激-阴部神经传导阻断模型的新型分体植入式神经调控微系统。该闭环系统由多个分体植入的脊髓神经记录、阴部神经传导阻断与骶神经诱发节点组成，旨在系统性调控神经系统，实现脊髓损伤患者的自由有效排尿。课题拟分析排尿行为、脊髓神经电活动、骶神经电刺激、阴部神经传导之间的对应关系，建立分体式脊髓神经调控相关机制模型；研究排尿行为相关的脊髓神经信号的分析识别方法，研制低功耗高集成度的脊髓神经记录微系统；研究骶神经前根刺激及阴部神经传导阻断的相关机制，研制具有诱发和阻断功能的高效率多模式神经电刺激器；研究分体式植入设备的供电方法，研究以脊椎或脊髓硬膜为媒介的体信道基带传输技术，实现各记录、刺激及阻断节点间的低功耗通信；所设计的微系统或关键模块拟进行在体动物实验验证。

中文关键词： 膀胱功能恢复；数模混合电路；超低功耗；闭环神经调控；体信道传输

英文摘要： This project plans to develop a split implanted neural modulation microsystem for bladder-dysfunction restoring, which is based on a new treatment model of spinal cord nerve recording - sacral nerve stimulating - pudendal nerve blocking and suitable for minimally invasive surgery. This close-loop system consists of several split implanted nerve recording nodes, nerve stimulating nodes and nerve blocking nodes, aims at modulating nerve system systematically and preventing urinary complications, so as to achieve the goal of freely controllable urination after spinal cord injury. We will analysis the relationship between the urination behavior, spinal cord nerve activity, sacral neural stimulation and pudendal nerve conduction and building relevant mechanisms models for split nerve modulation system. We will research and develop a spinal cord neural recording microsystem with the properties of low-power and high-integration and summarize the special methods for analyzing the urination-related activities of spinal cord nerve. We will research the relevant mechanisms of sacral nerve anterior root stimulating and sacral nerve posterior root / pudendal nerve blocking, and develop a high-efficiency multi-modes nerve stimulator with the functions of neural evoking and blocking. We will research the power supply technologies for split implanted system. In order to realize the low power communication between the implanted nodes of nerve recording, nerve stimulating and nerve blocking, we will develop a body channel communication technology by spinal column or spinal dura mater. The implantable micro-system or key modules plan to be verified through in-vivo test.

英文关键词： Bladder-dysfunction restoring;Digital/analog mixed circuit;Ultra low-power;Close-loop neuro-modulation;Body channel communication