低芥酸菜籽油的抗氧化成分对心脑血管疾病风险因子的干预作用

项目名称： 低芥酸菜籽油的抗氧化成分对心脑血管疾病风险因子的干预作用

项目编号： No.31271856

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 农业科学

项目作者： 黄凤洪

作者单位： 中国农业科学院油料作物研究所

项目金额： 78万元

中文摘要： 低芥酸菜籽油（芥酸含量小于5%）因能减少心脑血管疾病发生风险而备受关注，油脂中抗氧化成分是影响其功能大小和稳定性的关键因素之一。但低芥酸菜籽油中抗氧化成分包括多酚、生育酚、辅酶Q、植物甾醇和类胡萝卜素等形成的抗氧化体系，对油脂降低心脑血管疾病发生风险的干预作用和机制还不明。基于此，针对导致心脑血管疾病的重要风险因子，以正常饮食和高脂饮食金黄地鼠为研究对象，同时结合体外细胞水平评价和抗氧化试验，分别系统研究低芥酸菜籽油的内源性和外源性抗氧化体系（由不同种类、含量和结构的抗氧化成分构成），对心脑血管疾病风险因子包括脂质代谢紊乱、脂质过氧化和炎症因子等的干预作用，以揭示低芥酸菜籽油中抗氧化体系对油脂活性的影响规律，获得有利于预防心脑血管疾病的抗氧化体系的优势组成和含量，为增强低芥酸菜籽油降低心脑血管疾病发生风险功能及其稳定性提供理论依据，为提高油脂的营养价值和提升国民健康水平提供科技支撑。

中文关键词： 低芥酸菜籽油；抗氧化成分；心脑血管疾病；风险因子；干预作用

英文摘要： Low erucic acid rapeseed oil (erucic acid ≤ 5%) has attracted more attention recently due to reducing the incidences of cardiovascular disease, and the antioxidant components in oils are the key factors affecting their function and stability. The antioxidant components in low erucic acid rapeseed oil include polyphenol, tocopherol, coenzyme Q, phytosterol and carotenoids, and the intervention effect and mechanism of the antioxidation system in alleviating associated cardiovascular risk factors are still unknown. Based on the above analysis, according to the key cardiovascular risk factors, took hamsters fed normal and high-fat diet as the research object, and combined with cell level evaluation in vitro and anti-oxidation experiment, the intervention effect of endogenous and exogenous antioxidant system in low erucic acid rapeseed oil (composed by different kinds, contents and structures of antioxidant components ) on the cardiovascular disease risk factors (lipid metabolism, lipid peroxidation and inflammatory factors) are studied respectively, so as to reveal the effect of antioxidant system on the bioactivity of low erucic acid rapeseed oil, gain the advantage composition and content of antioxidant system which benefit the prevention of cardiovascular diseases, provide a theoretical basis for enhancing the pr

英文关键词： low erucic acid rapeseed oil；antioxidants；cardiovascular disease；risk factors；intervention effect