凝胶网络构筑的超声调控及流变性质研究

项目名称： 凝胶网络构筑的超声调控及流变性质研究

项目编号： No.10874015

项目类型： 面上项目

立项/批准年度： 2009

项目学科： 生物科学

项目作者： 王荣瑶

作者单位： 北京理工大学

项目金额： 36万元

中文摘要： 分子凝胶的形成是一个热力学和动力学控制的过程，如何描述分子凝胶复杂的形成动力学以及如何理解动力学调控与凝胶纤维网络微结构工程之间关联的物理本质，一直是分子凝胶材料研究的一大难点。本课题从深入理解分子自组装纤维网络的成核生长动力学入手，研究了超声刺激在调控凝胶网络成核-生长动力学的作用，探索了动力学调控纤维分叉和生长以及网络节点的形成和分布的新的物理原理和方法。紧跟当前智能凝胶软物质研究的发展趋势，我们进一步开展了有机分子-金属纳米微粒的杂化自组装/自组织体系的研究，构建了具有表面等离子光学性质的一维软纳米线性链及其手性超结构，并探索了软纳米线性链结构独特的光学性质在生物分子识别上的应用。我们相信这项研究不仅有助于设计和构建新型的微/纳纤维网络结构材料、优化网络微结构相关的性能表达，而且为进一步研究新型表面等离子体软功能材料在生物医学方面的应用提供帮助。

中文关键词： 软物质；纳米纤维网络构筑；分子凝胶网络结构与流变性质；表面等离子体手性超结构

英文摘要： Formation of molucular gel is governed by both thermodynamics and kinetics.How to describe the complictaed gelation kinetics and how to understand the physical basis that links between the kinetic control and the micro-/nanostructural engineering are the challenging tipoics in the research field of gel materials.This project has studied the nucleation-and-growth kinetics of gel network to gain a deeper understanding of the kientic control of molecular gel formation. Based on these understandings that establish the relationship between the kinetic control and the micro-/nanostructural engineering of gel network,we have studied the ultrasound-stimulating formation of gel networks to identify the roles of ultrasound stimulus in regulating the nucleation and growth kinetics of gel network.Our effort has also been made to explore new principle and method of manipulating the branching behaviors and the distribution of nodes in the development of fiber network, with the goal to establish the relationship between the tunable fiber network microstructures and the controllable macroscopic properties of molecular gel materials. Furthermore,to follow the research advance in the inteligent gel materials, we have extended our studies to the self-assembly system comprised of molecules and nanoparticles. Particularly, we have constructed some soft linear chains of metal nanoparticles and their chiral superstructures, whose unique plasmonic properties demonstrated their promising applications in biomolecular sensing. These research works would be helpful in engineering micro-/nanostructur of fiber network functional materials, so as to achieve the optimized structure-directing macroscopic properties/functionalities, and moreover our work would also open up a new route to create novel soft functional materials with plasmonic properties for biomedicine applications.

英文关键词： soft matters; nano-fiber network architecture; network structure and rheological properties of molecular gels; chiral plasmonic superstructure.