超高压诱导胶原蛋白明胶化机理研究

项目名称： 超高压诱导胶原蛋白明胶化机理研究

项目编号： No.31301425

项目类型： 青年科学基金项目

立项/批准年度： 2014

项目学科： 农业科学

项目作者： 张宇昊

作者单位： 西南大学

项目金额： 22万元

中文摘要： 传统的明胶生产工艺过程主要采用酸碱诱导胶原明胶化，存在着生产效率低、污染严重等问题。前期我们对超高压技术替代酸碱处理制备明胶工艺进行了探索，发现超高压处理可有效诱导胶原明胶化，同时显著提高明胶的凝胶特性。基于此，本课题拟对超高压诱导胶原蛋白明胶化机理进行深入研究。首先研究超高压诱导后明胶化胶原热力学特性和微观结构，明确明胶化胶原的较优热力学状态和特征结构，在此基础上采用分子模拟的方法，研究超高压诱导胶原蛋白明胶化全过程中胶原变化的动态特性和分子机制，最终构建可描述该过程中胶原蛋白热力学状态和明胶化特征结构变化的机理模型，解析超高压诱导胶原蛋白明胶机理。旨在通过以上研究为超高压技术在明胶产业化中应用乃至环境友好型明胶生产工艺的建立奠定理论基础。

中文关键词： 超高压；胶原；明胶；分子机制；

英文摘要： The traditional processing of gelatin, using acid and alkali to induce collagen tending to gelatin, has some problems such as low efficiency, serious pollution and so on. We studied the processing of gelatin by and proved that ultra-high pressure could induce collagen tending to gelatin effectively, as well as improve the gel properties of gelatin. The project will study the mechanism of collagen tending to gelatin induced by high pressure based on the preliminary results. Firstly, the thermodynamic character and micromechanism of collagen after ultra-high pressure will be studied, and the best thermodynamic status and special structure of collagen tending to gelatin will be confirmed. Based on that, the dynamic characteristics and molecular mechanism , during the whole course of collagen tending to gelatin induced by ultra-high pressure, will be studied using the method of molecular simulation, Then the mechanism model that could explain the change of thermodynamic status and special structure of collagen tending to gelatin during the whole course will be build , the mechanism of collagen tending to gelatin induced by high pressure will be uncoverd. The results of the project is meaningful to decrease pollution during gelatin processing and improve the technology of gelatin processing.

英文关键词： high pressure；collagen；gelatin；molecular mechanism；