神经内分泌因子生长抑素调控硬骨鱼类生长和糖脂代谢的协同机制研究

项目名称： 神经内分泌因子生长抑素调控硬骨鱼类生长和糖脂代谢的协同机制研究

项目编号： No.31472259

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 农业科学

项目作者： 李文笙

作者单位： 中山大学

项目金额： 88万元

中文摘要： 本项目把传统的神经内分泌因子生长抑素作为一种新的脑肠肽，从一个全新的角度开展生长抑素对鱼类糖脂代谢的分子调控机制研究，特别是结合生长抑素在生长调控轴中的作用机制，进行生长和糖脂代谢的协同机制研究。通过离体和在体实验，从分子水平上探索生长抑素对鱼类糖脂代谢的调控机理，阐明鱼类糖脂代谢的分子机制，为鱼类神经内分泌学和分子营养学增添新的内容；同时，开展糖脂代谢中间产物对生长调控因子的反馈作用的研究，阐明生长抑素调控生长和糖脂代谢的协同机制。研究结果将为揭示神经内分泌系统和消化系统之间存在着密切的内在联系提供新证据，为进一步提高鱼体生长率和饲料利用效率，促进鱼类养殖业发展提供新的理论和思路。

中文关键词： 生长抑素；生长；协同机制；糖脂代谢；硬骨鱼类

英文摘要： Somatostatin has been well known as a neuroendocrine factor playing pivotal role in the regulation of teleost growth. Based on the previous studies from our lab and other colleagues, somatostatin is highly expressed in both central nervous system and digestive systems. In the present study, we will put somatostatin as a new kind of gut-brain peptide. From a new angle, we will carry out the research focusing on the somatostatin effect on the regulation mechanism of fish glucolipid metabolism using grouper as a model. Meanwhile, the negative feedback of intermediate metabolites on gene expression of SS and its receptors will be illuminated. By in vitro and in vivo experiments, we will explore the effect of somatostatin on glucolipid mechanism from the molecular level, we hope the new data will give us new knowledge about fish molecular nutrition. It is suggested that there is a close inner link between neuroendocrine system and digestive system. We believe that the new findings about somatostatin synergy mechanism on regulating growth and glucolipid metabolism will provide new evidence to support the hypothesis. We also firmly believed that our results will provide new theories and ideas to improve the fish growth rate and feed efficiency in aquaculture.

英文关键词： somatostatin;growth;coordination mechanism;glucolipid mechanism;teleost