含生物可降解嵌段的氢键键合两亲性超分子共聚物的胶束化与溶液自组装

项目名称： 含生物可降解嵌段的氢键键合两亲性超分子共聚物的胶束化与溶液自组装

项目编号： No.21274128

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 数理科学和化学

项目作者： 潘鹏举

作者单位： 浙江大学

项目金额： 76万元

中文摘要： 由于核酸碱基互补氢键高度的选择性和可逆性，核酸碱基是构筑超分子聚合物的一种理想结构单元，也是实现可控自组装的有效途径。本课题将以聚乳酸（PLA）和聚乙二醇（PEG）为例，制备核酸碱基为端基的PLA和PEG，利用PLA:PEG两亲性超分子共聚物的溶液自组装，制备氢键键合聚合物胶束材料。将利用DLS、SLS、TEM、AFM和同步辐射SAXS研究胶束的结构形貌和物理性能（如稳定性、环境响应性），将研讨共聚物中成核嵌段（复合）结晶化、亲/疏水嵌段间键合方式、外界条件（如温度、pH值）对氢键键合胶束结构形貌和性能的影响规律及机理。本项目制备的环境响应性超分子聚合物胶束将有望用于药物可控释放、化学传感器领域。本研究将提供一种同步辐射SAXS法分析非共价键合胶束精密结构和通过控制成核嵌段聚集态结构调控胶束结构和物理性能的新方法，将有助于进一步理解具有多层次相互作用、弱键键合软物质体系自组装的规律与理论。

中文关键词： 超分子共聚物；多重氢键；胶束；小角X射线散射；聚乳酸

英文摘要： Nucleobase is an ideal building block for supramolecular polymers and constructing the nucleobase H-bond is an efficient approach for the controllable and programmable molecular self-assembling, because of the high selectivity and reversibility of H-bond between the nucleobase pairs. In this project, we would like to select poly(lactic acid) (PLA) and poly(ethylene glycol) (PEG) as the model blocks and synthesize the nucleobase-terminated PLA and PEG. The nucleobase H-bond connected copolymeric micelles will be prepared through the solution self-assembly of the PLA:PEG supramolecular amphiphilic block copolymer in aqueous media. The structure, morphology, and physical properties (e.g., micellar stability and stimuli responsivity) will be investigated via DLS, SLS, TEM, AFM, and synchrotron radiation SAXS techniques. The effects of crystallization, stereocomplex crystallization of the core-forming block, connection mode between the hydrophilic and hydrophobic blocks, and the environmental conditions (e.g., temperature and pH) on the structure/morphology and physical properties of the H-bond connected micelles will be investigated. The stimuli-responsive supramolecular copolymer micelles prepared in this work will find potential applications in the controlled drug release and chemical sensing. This study will prov

英文关键词： Supramolecular copolymer；multiple hydrogen bonds；micelle；SAXS；poly(lactic acid)