基于牺牲空间策略的分子印迹杂化物的设计、合成及其在POPs分析中的应用

项目名称： 基于牺牲空间策略的分子印迹杂化物的设计、合成及其在POPs分析中的应用

项目编号： No.21274022

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 数理科学和化学

项目作者： 童跃进

作者单位： 福建师范大学

项目金额： 82万元

中文摘要： 本项目以多溴二苯醚、二噁英和硫丹三类含氧持久性有机污染物（POPs）的代表物五溴代二苯醚、四氯代二噁英和α-硫丹为印迹模板分子；依据"牺牲空间"分子印迹的策略，分别设计和合成三种模板分子的替代物，对替代物进行改性并键联到硅氧烷，经溶胶-凝胶化和脱除模板替代物以制备分子印迹杂化物（MIHs），解决含氧POPs反应活性的转换并建立空间间隔基团的引入和去除方法；研究所得MIHs对模板分子的识别行为及对模板分子结构相似物的竞争性结合能力，揭示MIHs的识别机理，筛选出最优的模板替代物、空间间隔基团及与硅氧烷的组合。进一步以MIHs为敏感材料与碳基材料复合，深入探讨电化学传感界面组成、形态和构筑方法对最终电极传感性能的影响，获得可以指导新型分子印迹电化学传感器设计和制备的基础数据。该项目还可为上述含氧POPs同系物以及其他类型POPs的分子印迹与分析检测提供理论及科学实验依据。

中文关键词： 分子印迹杂化物或聚合物；牺牲空间法；模板替代；多溴二苯醚；分子识别

英文摘要： Pentabromodiphenyl ether, tetrachloro dioxin and α-endosulfan will work as template, representing POPs containing oxygen such as polybrominated diphenyl ethers, dioxin and endosulfan. The substitutes of these templates should be designed and synthesized based on the "sacrificial spacer" strategy followed by the modification of substitute and the connection of siloxane to the substitute. The molecularly imprinted hybrids (MIHs) will be further synthesized by a sol-gel procedure and the removal of substitute and spacer, aiming at the transformation of reactivity in POPs containing oxygen and establishment of introduction and removal of spacer. Therefore, the recognization mechanism of MIHs can be expounded and the optimization of template, spacer and the conbination with siloxane can be made after investigating the recognization behaviour to the templates and the competive binding capability for the template analogues. The MIHs obtained above, playing an role of molecular recognition element, will then be mixed with conducting carbon-based substance. The effect of component, morphology and fabrication of sensor on the sensing ability will be studied as a result of obtainment of basic data indicating the design and fabrication of electrochemical sensor. The strategy in MIHs preparation is expected to extended to th

英文关键词： Molecularly imprinted hybrid or polymer；sacrifice space approach；template substitution；Polybrominated diphenyl ethers；molecular recognition