表面增强拉曼旋光（SEROA）光谱研究

项目名称： 表面增强拉曼旋光（SEROA）光谱研究

项目编号： No.21473115

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 数理科学和化学

项目作者： 王培杰

作者单位： 首都师范大学

项目金额： 85万元

中文摘要： 手性分子的构型不能与其自身的镜像相吻合,此类分子具有拉曼光学活性(ROA)也称拉曼旋光,主要表现在手性分子的同一个振动模对于左右园偏振的激光具有不同的拉曼散射截面，它所测量的物理过程比经二次电偶极矩作用的拉曼散射过程更深一个层次，牵涉到分子振动引致的电偶极矩与磁偶极矩和四极矩的相互作用过程。因此，ROA反映着分子内更为细致，也更为丰富的有关立体结构的信息，在手性药物研究、手性催化和生命科学研究领域发挥重大作用。但由于ROA信号很弱，极大地限制了它的实际应用和研究意义，因此，将表面增强技术与ROA结合，通过制备石墨烯隔离的纳米金属表面增强基底，获得稳定的，高灵敏度的手性分子的表面增强拉曼旋光（SEROA）光谱，是本课题主要研究内容和研究目标。进一步，我们将从SEROA峰强出发，求取手性分子的微分键极化率，由此对手性分子与表面或界面的相互作用及SEROA产生机理进行深入研究。

中文关键词： 表面增强拉曼旋光光谱；微分键极化率；表面等离子体共振；拉曼光学活性；石墨烯

英文摘要： The configuration chiral molecular cannot be superimposed on its mirror image. These kinds of molecule possess Raman optical activity (ROA), also called Raman rotation.The main performance of ROA is the differential Raman scattering of left circularly polarized and right circularly polarized incident laser. The physical process measured by ROA is more profound than the Raman scattering process which only involves the interaction of electric dipole with electric dipole . But the ROA process involves the interactions of electric dipole with magnetic dipole and electric dipole with electric quadrupole. Therefore, ROA reflects more closer and more extensive intra-molecular information about the stereo-structure of chiral molecule. It will play an important role in the field of chiral catalyst, pharmaceutical research and life sciences. But ROA signal is very weak which greatly limits its practical application and research significance.Therefore, to get stable, high-sensitive surface-enhanced Raman optical activity (SEROA) spectrum of chiral molecules, is the main objective and content of the project by combining the surface-enhanced technology ROA through preparation of graphene isolated Nano metal surface enhanced substrates. Furthermore, from SEROA peak intensity, we can obtain the differential bond polarizability of chiral molecules by which we can analyze the interaction of chiral molecules with surfaces or interfaces and the mechanism of SEROA .

英文关键词： surface enhanced Raman optical activity(SEROA) spectroscopy;differential bond polarizability;surface plasmon resonence（SPR）;Raman optical activity(ROA);graphene