多模式轮烷分子机器的合成及其自组装

项目名称： 多模式轮烷分子机器的合成及其自组装

项目编号： No.21272073

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 数理科学和化学

项目作者： 曲大辉

作者单位： 华东理工大学

项目金额： 80万元

中文摘要： 本研究创新构建新型多模式轮烷型分子机器体系，将多个具有光电活性的功能分子单元集成到同一轮烷体系中，在外界刺激组合下多模式调控轮烷体系各功能基团之间的电子、能量转移等相互作用，并能带来体系荧光、吸收等可肉眼识别信号的显著变化；在轮烷杆状分子的两个识别点之间引入光异构化二苯乙烯或者偶氮苯等作为"闸"单元，利用"闸"来操控环状组分在两个识别点间的运动，构建可调控的多稳态分子开关、双向分子锁、分子时序逻辑等新概念功能体系；筛选性能优异的酸碱控轮烷型分子机器体系，对这些轮烷分子的端基进行合理的修饰，利用自组装的方法等方法将其固载到金电极、石英或者玻璃表面，来增大分子机器运行空间，研究分子机器在界面的协同运动以及运动过程对界面物理、化学性质的影响，为发展新型的功能自组装体系和发展分子机器的微流体器件打下基础。

中文关键词： 分子机器；轮烷；多模式；刺激响应；组装

英文摘要： This project aims to construct a series of novel multi-mode-driven rotaxane molecular shuttles, in which several functional units with excellent electronic/optic properties are integrated. In this kind of multi-functional molecular systems, multi-mode regulation of intercomponent interactions, such as electron transfer and energy transfer processes between functional units can be achieved in response to external stimuli, accompanying remarkable changes in the output signals, such as fluorescence and color changes. In this kind of rotaxane molecules, substituted stilbene or azobenzene moieties will be introduced into the dumbbell-shaped molecules of the rotaxane systems and situated between the two different recognition sites. The photoactive units can function as "brake" units and can be used to manipulate the movement of the macrocycle component between two recognition sites. This kind of rotaxane molecular shuttles can be utilized to construct novel-concept functional molecular systems, such as adjustable multi-stable molecular switches, bi-directional molecular locks and molecular sequential logic devices. A series of anchoring groups will be introduced into the stoppering parts of chemically driven molecular shuttles that feature excellent electronic and optic properties. These modified rotaxanes with anchor

英文关键词： molecular machines；rotaxane；multi-mode；stimuli-responsive；self-assembly