基于蛋白质/多肽自组装模板的新型介孔催化材料设计

项目名称： 基于蛋白质/多肽自组装模板的新型介孔催化材料设计

项目编号： No.21474125

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 数理科学和化学

项目作者： 李朝旭

作者单位： 中国科学院青岛生物能源与过程研究所

项目金额： 86万元

中文摘要： 蛋白质/多肽可通过非共价键相互作用，自组装形成多种规整结构，并对无机材料的合成具有导向作用，是制备介孔催化材料的新型生物基模板，极具研究价值与应用前景。不仅有利于实现孔道的多样化、可控性、有序化，同时，基于蛋白质/多肽自组装结构可调的物理化学稳定性，便于在温和的条件下去除模板，从而为开拓无机介孔催化材料的绿色合成技术、催化性能优化及实用化提供了一条全新的手段。本课题拟控制特定的蛋白质或多肽自组装成为球状、纤维状与管状结构，并作为绿色模板，结合溶胶-凝胶法，合成无机介孔材料的骨架。通过研究模板对催化剂/酶的黏附作用、及模板的选择性降解方法，探索将不同种类的催化剂/酶固定于孔道内的有效途径,特别是对外界条件敏感的生物酶的包埋技术。该项目的成功实施，不仅将提供一系列新型介孔催化材料的绿色合成新途径，同时为理解介孔的物理化学特征、催化剂/酶的固定方法与其催化活性、稳定性之间的关系提供了重要的平台。

中文关键词： 自组装；蛋白质；模板合成；介孔材料；催化

英文摘要： Proteins/polypeptides combine the powerful abilities of self assembling into various ordered nanostructures and directing the synthesis of inorganic materials, being able to act as a novel type of bio-based template to synthesize inorganic mesoporous catalytic materials. By utilizing the assembled nanostrutures as template, not only harsh conditions are avoided to remove the template, but also the mesopores with varied geometries, chemical properties and degree of order can be achieved in a controllable way.This green synthesis method will open an unprecedent scenario to optimize the structures and catalytic properties of mesoporous materials with low cost and less ecological effect for industrial applications. The present proposal is aiming at controlling self-assembly of specific proteins/polypeptides into spherical,fibrous and tubular nanostructures, further acting as template to synthesize mesoporous materials through sol-gel chemistry. Various catalysts or enzymes will be incorporated or embedded into the mesopores by attaching them to the template surfaces through non-covalent interactions, followed by selectively removing the template after forming the inorganic skeletons, which is particularly critical for the enzymes whose activities are sensitive to harsh enviromental factors. It is expected that this planned research will bridge the synthesis of the bio-based assemblied nanostructures and the applications of mesoporous materials as diverse as in environmental pollution control,pharmaceutical chemistry and organic synthesis, providing a unique platform to understand the relationships between the mesopore structures and properties of the loaded catalysts.

英文关键词： self-assembly;protein;template synthesis;mesoporous material;catalysis