糖尿病视网膜病变患者MR脑结构与功能网络分析

项目名称： 糖尿病视网膜病变患者MR脑结构与功能网络分析

项目编号： No.81201079

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 影像医学与生物医学工程

项目作者： 戴慧

作者单位： 苏州大学

项目金额： 23万元

中文摘要： 关于糖尿病视网膜病变（DR）发病机制的大量研究认为是高血糖引发的微血管机制导致视网膜病变，近年来，有学者发现视觉通路的神经退行性改变早于视网膜血管病变。视觉通路的中枢结构与功能改变是否为DR的首驱发病机制呢？本项目拟通过建立动物模型研究DR大鼠脑组织的微观病理改变；运用3.0T MR脑结构与功能成像，基于MR脑结构与功能数据构建各组临床被试（DR组、糖尿病组、对照组）的脑结构与功能网络：（1）得到直观的可视化图像，直接反映脑结构与功能网络的拓扑关系；（2）得到可量化脑结构与功能网络的各种网络指标包括最短路径、度分布、聚类系数、全局效率等，通过各组间网络指标的多重比较探讨脑结构与功能网络的组间差异，通过DR各亚组（DR组根据临床严重性分为5个亚组）的网络指标与临床分期的相关分析探讨DR的网络指标与疾病临床严重性之间的相关性，以揭示脑网络分析在DR早期诊断中的价值，试图揭示DR的中枢致病机制。

中文关键词： 糖尿病；视网膜病变；脑结构分析；脑功能网络；

英文摘要： As previously demonstrated in the numerous researches on the pathogenesis of diabetic retinopathy (DR), micrangium changes of retina induced by hyperglycemia is deemed to be the incipient cause of retinopathy in patients with diabetic. However, the neurodegeneration of the retina, optic nerve, optic chiasm, lateral geniculate nucleus and optic radiation is found occurring earlier than the micrangium changes of retina in recent studies. Whether can the structural and functional changes of the visual pathway resulted from the neurodegeneration process probably be the earliest factor of DR? To further elucidate the hypothesis, experimental study will be set with DR group and control group, in which the differences of brain pathology between these groups will be studied; the structural and functional images of human brains will be obtained by using 3.0 tesla MRI machine with each subject in DR group (classified to five sub-groups according to the clinical severity), non-DR group (diabetic patients without DR), and controls group. Then, the brain structural and functional networks will be figured out based on the structural and functional images after complicated data processing. When the networks are successfully constructed, 1) visualized images are obtained to topologically describe the structure and function of b

英文关键词： Diabetes；retinopathy；brain structural analysis；brain functional network；