人工活性关节功能的体外评价及其仿生系统构建

项目名称： 人工活性关节功能的体外评价及其仿生系统构建

项目编号： No.51205303

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 机械工程学科

项目作者： 王玲

作者单位： 西安交通大学

项目金额： 25万元

中文摘要： 人工活性关节在传统人工关节的基础上，其骨软骨的修复和再生赋予了人工关节在体内长期服役的潜能。但是，目前在世界范围内还没有形成对关节活性组织的功能和长期服役性能进行预测和评估的公认的标准体系，从而影响了人工活性关节在临床上的应用和发展。本项目提出对人工活性关节组织进行体外长期功能评估的新思路，通过对人体关节运动、力和生物的仿生建模来构建关节体外功能测试评估系统。项目重点通过计算机数值模拟的方法研究关节系统中骨软骨的力学、生物学、摩擦学的仿生机理；探索力学、物理等因素对活性组织功能的影响；构建完备的人体活性关节体外长期的功能评估系统，实现全方位（力、摩擦、生物）、多角度（运动、各种步态）、多尺度的评估和测试。研究成果为组织工程骨软骨支架的设计和优化提供反馈，为软骨的修复和再生提供技术支持，有助于活性关节的临床前评估标准的制定和组织工程研究成果向临床应用的转化。

中文关键词： 关节软骨；仿生设计；功能评估；组织工程支架；生物摩擦学

英文摘要： Tissue engineered articular cartilage replacements represents a potential solution to the patients of trauma or degenerative arthritic disease, for bridging the two conventional treatments: pain control and total joint replacements. However, the lack of a long-term feasible functional evaluation methodology has been holding the progress of the clinical application back. Therefore, a brand new methodology of functionally evaluating the engineered cartilage in-vitro for a long-term purposes has been proposed, aiming to recruit an in-house developed joint simulator that simulates the realistic motion & loading of the natural joint system and offers long-term preservation of the graft, by integrating the mechanical environment as well as the biological circumstances together. The key issues tackled in this project include: to build the computational modeling of the integrated mechanics, physics mechanisms relating the joint system as well as the modeling of nutrient transport within the graft; to investigate the effect of single factors such as loading, motion, tribology on the tissue function; to set up the system of evaluating the functional engineered cartilage tissue for the evaluation & test in a way of multi-scale, multi-physics etc. This project is looking into supporting the cartilage repair & regeneration f

英文关键词： Articular cartilage；bionic design；functional evaluation；Tissue Engineered scaffold；biotribology