多控磁性核-壳微球Fe3O4@MOFs/GO的构筑及载药性能的研究

项目名称： 多控磁性核-壳微球Fe3O4@MOFs/GO的构筑及载药性能的研究

项目编号： No.51302071

项目类型： 青年科学基金项目

立项/批准年度： 2014

项目学科： 一般工业技术

项目作者： 李玲

作者单位： 湖北大学

项目金额： 25万元

中文摘要： 现有磁性核-壳微球普遍存在载药可控和靶向可控难以兼备的缺点，而高载药量、孔径可调的壳层材料和适当的壳层厚度是关键因素。本项目拟以Fe3O4磁性粒子为核，以孔径可调的金属有机骨架配合物（MOFs)和高比表面积的氧化石墨烯（GO）为复合壳层材料，通过层层自组装方法，设计合成多控Fe3O4@MOFs/GO磁性核-壳微球。通过调节MOFs中金属离子和配体的类型、MOFs/GO比例、自组装循环次数、反应温度等条件，合成不同壳层组成和壳层厚度的磁性核-壳微球，建立构筑磁性核-壳微球可控合成的新方法与新机制；重点研究磁性核-壳微球的壳层结构对磁性能及载药性能的影响规律，揭示磁性核-壳微球的合成-结构-性能的内在联系，获取Fe3O4@MOFs/GO靶向可控和载药可控的重要信息，为药物载体的设计和筛选提供理论和实验依据。

中文关键词： 磁性核-壳微球；可控合成；药物载体；载药可控；MOFs/GO

英文摘要： Magnetic core-shell microspheres can not simultaneously drug control and target control in the application. Shell material with high loading and adjustable pore size, and shell thickness are the key factors. The project intends to use Fe3O4 magnetic particles as the core, aperture adjustable MOFs ( metal organic framework ) and GO( graphene oxide )with high specific surface area for the composite shell materials.Using the layer-by-layer self-assembly method to design and synthesis multiple control magnetic core-shell microspheres Fe3O4@MOFs/GO. By adjusting the type of metal ions, ligand type, the proportion of MOFs/GO, the times of assembly cycle, reaction temperature to build different shell structure ( different shell composed and different shell thickness ) of the magnetic core-shell microspheres, a new method and mechanism of controllable synthesis on magnetic core-shell microspheres is constructed. We plan to focus on the effect of shell structure of composite microspheres on the magnetic properties and the drug loading properties , reveal the internal connecting link of magnetic core-shell microspheres in composition - structure - performance , access the important information of targeting controll and drug controll of Fe3O4@MOFs/GO,and provide theoretical and experimental basis for the design and scree

英文关键词： magnetic core-shell microsphoeres；control synthesis；drug carrier；drug loading control；MOFs/GO