低强度超声促进关节软骨修复的物理机制及优化研究

项目名称： 低强度超声促进关节软骨修复的物理机制及优化研究

项目编号： No.11204144

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 物理学I

项目作者： 邱媛媛

作者单位： 南通大学

项目金额： 25万元

中文摘要： 低强度超声有利于促进关节软骨修复，有效地对治疗行为进行指导与控制是获得优化的临床效果的关键。本项目旨在明确超声促进关节软骨修复的物理机制，并定量调控超声作用下的动力学行为。我们拟研究超声稳态空化效应在关节软骨修复中的作用机理，建立并实现体外兔软骨细胞超声无菌照射及被动空化检测实验系统，探讨稳态空化与软骨细胞生物效应的关系。我们还将理论及实验研究声流在超声促进软骨修复作用中的确切机制，一方面基于已有的声流理论模型，考虑超声在流体中传播时的热传导、空化核之间的相互作用，建立超声激励下的声流场理论模型，探讨声流场结构的超声调控；另一方面基于微尺度粒子速度成像系统，定量测量声流场及其产生的剪切力场，研究不同超声参数作用下声流流速及结构对软骨细胞及组织的影响，并进一步完善理论模型。本项目的研究将进一步促进低强度超声在骨关节炎临床治疗中的应用。

中文关键词： 声微流；骨关节炎；超声生物效应；超声空化；

英文摘要： It has been demonstrated that low intensity ultrasound is beneficial to promoting articular cartilage repair. How to effectively guide and control treatment behavior is in high demand in order to get the best clinical treatment result. The project is aimed to clarify the physical mechanism of ultrasound promoting articular cartilage's repair, and quantitative control of dynamical behavior under the effect of ultrasound. We will study the mechanism of stable cavitation in repairing articular cartilage, establish an experimental system of ultrasound sterile exposure and passive cavitation detection, investigate the relation between stable cavitation and chondrocyte bioeffect. Furthermore, we will theoretically and experimentally investigate the exact mechanism of acoustic streaming in ultrasound promoting cartilage repair. We will develop a theoretical model for acoustic streaming considering the interaction of heat conduction and cavitation nuclei, investigate the quantitative control of acoustic streaming field under ultrasonic exposure. For examining the theoretical analysis, we will measure the acoustic streaming field and the induced shear force based on the microscale PIV measuring system, discuss the effect of ultrasonic parameters on acoustic streaming velocity and structure, and improve further the theore

英文关键词： microstreaming；Osteoarthritis；ultrasound induced bioeffects；acoustic cavitation；