疼痛背景下的大脑前注意加工及其对慢性痛发展的预测作用

项目名称： 疼痛背景下的大脑前注意加工及其对慢性痛发展的预测作用

项目编号： No.31271092

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 医药、卫生

项目作者： 王锦琰

作者单位： 中国科学院心理研究所

项目金额： 78万元

中文摘要： 慢性疼痛性疾患的发生与发展涉及深层的认知机制，因而难以用简单的客观指标加以评价与预测。在疼痛的深层认知机制中，前注意加工可能具有重要地位，影响着疼痛的感受、反应与发展的整个过程。但其具体作用程度和机制不明。本项目综合运用行为学、电生理学、中枢神经药理学等手段，结合人类被试和动物模型，以脑电失匹配负波(MMN)为核心指标，考察不同疼痛状态对前注意加工的影响，探讨MMN与疼痛状态、疼痛经历及镇痛疗效间的关系，并分析其可能的中枢作用位点和受体机制，分析前注意网络在该现象群中的参与机制。这些研究将揭示疼痛与前注意加工过程之间的相互作用，说明前注意加工对慢性疼痛发生、发展、治疗与转归过程的可能的预测性，并进一步分析确定其中关键的影响因素和神经机制。有关结果不仅将加深对慢性疼痛发病过程的理论认识，而且可能为临床疼痛的治疗和预后判断提供重要依据，具有重要的理论意义和潜在的临床应用前景。

中文关键词： 急性痛；听觉诱发电位；慢性痛；认知损伤；失匹配负波

英文摘要： Intrinsic cognitive mechanisms are involved in the occurrence and development of chronic painful conditions, thus posing great challenges to the evaluation and prediction of chronic pain using simple objective measures. Preattentive processing may play an important role in those underlying cognitive mechanisms of pain, affecting pain sensation, response and development. However, the exact magnitudes and mechanisms of these effects remain unclear. Using behavioral, electrophysiological and neuropharmacological methods, the current project seeks to investigate the influences of various pain states on preattentive processing indexed by the mismatch negativity (MMN) in human subjects and animal models. Studies are designed to examine the relevance of MMN to pain states, pain experiences and treatment outcomes. Possible central sites and receptors involved and the role of neural networks for preattentive processing in those phenomena will be analyzed as well. These studies may elucidate the interaction between pain and preattentive processes, evaluate the predictive ability of preattentive processing for the occurrence, development, and treatment outcomes of chronic pain, and further identify the critical influencing factors and neural mechanisms of the above-mentioned effects. The results will not only lead to a bet

英文关键词： acute pain；auditory-evoked potentials；chronic pain；cognitive impairment；MMN