真实与错误记忆的基因研究

项目名称： 真实与错误记忆的基因研究

项目编号： No.31200850

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 学习与记忆

项目作者： 朱皕

作者单位： 北京师范大学

项目金额： 20万元

中文摘要： 记忆是人类智力的核心，更是人类生存和发展所必须的基本功能。真实记忆是对过去感知信息和事件的准确再现，错误记忆是对从未体验的事件产生回忆或混淆了目标事件和它发生前后的多个事件。但以往研究没有综合探讨多基因及其与环境交互作用对真实和错误记忆的影响。本项目将采用两种记忆行为任务和基因型测查技术，考察多基因及对人类真实与错误记忆的影响，以及环境对基因与记忆关系的调节作用。首先，采用多巴胺和五羟色胺基因，研究真实记忆与错误记忆遗传基础的异同，完善记忆的激活-监控理论；其次，研究生活环境压力对于真实记忆与错误记忆遗传基础的调节作用。本项目将有助于揭示真实记忆与错误记忆的遗传基础，还有助于开发出有效的方法来提高学习和教育的效率或鉴别刑事案件中目击者记忆的准确性和可靠性。申请人具有记忆行为研究和分子遗传研究基础，以第一作者已发表SCI/SSCI论文五篇，这些研究经验将保证本项目的顺利实行。

中文关键词： 真实记忆；错误记忆；基因关联；神经递质；人类记忆与学习

英文摘要： Human memory is an essential part of human intelligence, and it is a critical function for the survival and development of human beings. True memory refers to the correct retention of information. False memory refers to the memory distortion in which people sometimes develop vivid and detailed recollections of events that were never experienced; or people confuse events that happened before or after the target event with the event itself. Previous studies did not address the contributions of dopamine and serotonin-related genes and environmental factors to both true and false memories. The current study will explore the genetic variation in dopamine and serotonin systems and true and false memories induced by two different kinds of paradigms (misinformation and DRM), and gene-environment interactions on true and false memories. First, we will genotype the candidate genes in dopamine and serotonin systems, explore the similarities and dissimilarities of genetic basis of true and false memories, and promote the development of activation-monitoring memory theory. Secondly, we will study the moderation effect of life event stress on genetic variation and true or false memories. This research will be helpful to develop a valid method to improve memory accuracy in study and education performance, or to predict what ki

英文关键词： true memory；false memory；genetic association；neurotransmitter；human memory and learning