项目名称: 手性纳米主体材料修饰电极对氨基酸类药物的识别研究
项目编号: No.21272188
项目类型: 面上项目
立项/批准年度: 2013
项目学科: 数理科学和化学
项目作者: 傅英姿
作者单位: 西南大学
项目金额: 80万元
中文摘要: 手性化合物是生物体的基本组分,化合物的一对对映体在生物体内的药理活性、代谢过程、代谢速率及毒性等存在着显著的差异,一种构型具有正向生物效应,相反构型可能有拮抗,甚至致癌、致畸、致突变等毒副作用;因此手性识别研究具有重要的理论意义和实际应用前景,发展简单、准确、快速、灵敏的手性识别方法和传感器成为近年来化学领域的热点方向。申请者拟利用化学物理方法设计手性纳米主体材料,通过电化学和光化学等手段深入研究手性纳米主体材料直接修饰电极和电活性无试剂型手性纳米主体材料修饰电极对氨基酸类药物的识别作用,发展对氨基酸类药物具有选择性识别的手性传感器,并进一步构建无试剂手性传感器。这些工作不仅可以为手性药物的研究提供有效参考,还将帮助我们进一步认识和理解生命过程的化学本质。拓展了手性识别研究新方向。
中文关键词: 手性纳米主体材料;修饰电极;氨基酸类药物;识别;
英文摘要: Chiral compound is the basic component of living body. Different architectonic chiral compounds can exhibit distinct function in pharmaco-activity, metabolic process, metabolic rate and toxicity. A pair of chiral drugs may exhibit very di?erent medical e?ects toward patients. One enantiomer may be e?ective for a kind of disease, while the other one may be ineffective or toxic. Chiral recognition is becoming one of the frontiers in chemistry. Hence, we will utilize the novel chiral host nanomaterials modified electrodes to design and fabricate chiral surface which with chrial recognition and sensing efficiency, develop the new electrochemical method and the reagentless sensor in chiral recognition of amino acid drugs. Such work may not only offer valuable reference to the research of chiral drugs, but also help to comprehend the essence of life. It open a new window to the chiral recognition.
英文关键词: Chiral host nanomaterials;Modified electrode;Amino acid drugs;Recognition;