YKL-40水平及CHI3L1基因多态性与高血压发病关系的研究

项目名称： YKL-40水平及CHI3L1基因多态性与高血压发病关系的研究

项目编号： No.81502867

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 医药、卫生

项目作者： 徐添

作者单位： 南通大学

项目金额： 18万元

中文摘要： 炎症反应和内皮功能异常是高血压发病的重要机制。研究显示，人软骨糖蛋白-39（YKL-40）是一种新型炎症和内皮功能标志物，一些小样本人群研究提示YKL-40水平与高血压患病风险呈正相关，YKL-40的编码基因CHI3L1也与炎症性疾病存在一定关联，然而目前尚无YKL-40水平及CHI3L1基因多态性与高血压发病关系的大样本人群研究。本项目将在2007-2008年已建立的大规模（18550例）健康人群队列的基础上，采用1:1匹配的巢式病例对照的研究方法，选取800例新发高血压病例和相应对照，进行基线YKL-40水平及CHI3L1基因上7个主要SNPs的检测，探讨YKL-40水平、CHI3L1基因多态性以及它们与传统危险因素的交互作用对高血压发病的影响。本研究将为YKL-40水平及CHI3L1基因多态性与高血压发病的关系提供重要的流行病学证据，也将为高血压的发病机制研究以及药物研发提供新思路。

中文关键词： YKL-40；CHI3L1基因；多态性；高血压

英文摘要： Inflammation reaction and endothelial dysfunction are important mechanisms of hypertension. Some studies suggested that human cartilage glycoprotein 39(YKL-40) was a new biomarker of inflammation and endothelial function. Some small-sample population studies indicated that YKL-40 level was positively correlated with hypertension prevalence risk. CHI3L1 gene which encodes YKL-40 was also associated with the inflammatory diseases. While large-sample population studies on YKL-40 level, CHI3L1 polymorphism and hypertension incidence were not reported at present. We would conduct a 1:1 matched nested case-control study based on a large-sample general population cohort of 18550 participants from 2007 to 2008. Baseline serum YKL-40 levels and seven major SNPs in CHI3L1 gene will be tested among 800 new hypertension cases and corresponding controls, in order to investigate the association between YKL-40 level, CHI3L1 gene polymorphism, the interaction between them and traditional risk factors and hypertension incidence. Our study will provide vital epidemiology evidence for the association between YKL-40 level, CHI3L1 gene polymorphism and hypertension, and new insights into the disease mechanisms of hypertension and drug discovery.

英文关键词： YKL-40;CHI3L1 gene;Polymorphism;Hypertension