项目名称: 基于自供电原理的可植入式葡萄糖生物传感器建模研究
项目编号: No.21471158
项目类型: 面上项目
立项/批准年度: 2015
项目学科: 数理科学和化学
项目作者: 张祥成
作者单位: 中国科学院苏州纳米技术与纳米仿生研究所
项目金额: 80万元
中文摘要: 本项目基于电化学传感器检测机理,应用仿生基本原理,以生物燃料电池为研究平台,以电化学阻抗等在线表征方法为手段,利用微加工技术制备纳米电极材料,结合物理/化学改性方法智能调控电极表面性能以构建仿生界面,用于固定、活化生物酶,研究酶与电极间的直接电子传递过程,建立相应的葡萄糖生物电池与生物传感器联用理论模型,为自供电可植入式葡萄糖生物传感器研究奠定方法学基础,突破可植入式葡萄糖传感器研究在功率与时效上的局限性,开拓生物燃料电池在线表征、监测体液葡萄糖的新思路与方法,为自供电式葡萄糖生物传感器的前瞻性研究奠定研究和技术手段,也为未来植入式微型人工电子器件在体能源等应用性研究找到突破口。重点研究:基于自供电葡萄糖传感器研究平台及其生物相容性;电极的微/纳多尺度结构与表面性能的智能调控;在线联用方法表征酶、电极之间电子转移;电池、传感器联用模型的建立;多种影响因素对生物传感器性能稳定性及精度的影响。
中文关键词: 表面结构与性能;可植入式;连续监测;自供电;生物传感器
英文摘要: This project is based on electrochemical sensor detection mechanism, bionics as the basic principle, the bio-fuel cell as a research platform, and the electrochemical impedance online characterization methods as a means of preparing the electrode array using ultra micromachining technology. The bionic interface is constructed by a combination of physical/chemical modification and surface properties intelligent control of the electrodes, to be used for enzyme immobilization and activation, and study direct electron transfer processes by enzyme and the electrode. A theoretical model of glucose biofuel cells and biosensors is built to establish a methodology basement for study self-powered potentially implantable glucose biosensors. In order to break through the limitation of time and power in potentially implantable glucose sensor research and open up new idea and method for biofuel cell online characterization and in vivo glucose monitoring. Aim to create prospective research and technology method for self-powered glucose biosensor and to find a breakthrough in body energy for implantable miniature electronic devices applied research in the future .
英文关键词: surface structure and property;potentially implantable;continuous monitor;self-powered;biosensor