基于稠环及多芳基咪唑长波长荧光分子探针的设计及接力识别性能研究

项目名称： 基于稠环及多芳基咪唑长波长荧光分子探针的设计及接力识别性能研究

项目编号： No.21506106

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 有机化学

项目作者： 赵冰

作者单位： 齐齐哈尔大学

项目金额： 21万元

中文摘要： 本项目以构建具有高荧光发射波长的主体化合物为基础，设计稠环咪唑及多芳基咪唑衍生物，通过氯乙酰化和氨基化反应设计出含有多个识别位点的共轭咪唑类荧光分子化合物。所设计的荧光分子由于含有多个酰胺基、羰基等基团，增加它们在水中的溶解度。在水溶液中，荧光分子实现对客体金属离子的识别后，加入特定的阴离子，利用金属离子在水中形成难溶物的机理，实现共轭咪唑衍生物在水溶液中的接力识别。项目中分别讨论信号体、受体结构对咪唑衍生物识别性能的影响，并通过多种方式表征主体分子与客体分子之间的识别作用，确定咪唑荧光分子与客体识别的作用机制，以指导其他咪唑衍生物对客体的识别行为。

中文关键词： 咪唑；荧光探针；接力识别；机理研究

英文摘要： Based on the construction of long-wavelength fluorescence probes with high emission wavelengths, conjugated fused-ring and poly-aryl imidazole derivatives with various recognition sites were designed and synthesized by the chloroacetyl and amination reactions. Fluorescent molecules synthesized have favorable water-solubility due to the poly amide groups and carbonyl groups. After the fluorescent molecules achieve recognition of the object (metal) in the aqueous solution, the addition of the special anions promote the realization of the relay recognition because of the formation of insoluble metal-salt. The effects of the signal bodies and the structures of the objects to recognition properties also were discussed in this project and the recognition actions between the host and guest were characterization by the multi-ways. The action mechanism between the imidazole fluorescent molecules and objects are determined, which could conduct the recognition behaviors of the other imidazole derivatives.

英文关键词： imidiazole; fluorescent probes ;relay-recognition ;mechanism