高效稀土催化体系的开发及其在催化有机多组分反应中的应用

项目名称： 高效稀土催化体系的开发及其在催化有机多组分反应中的应用

项目编号： No.20872106

项目类型： 面上项目

立项/批准年度： 2009

项目学科： 金属学与金属工艺

项目作者： 徐凡

作者单位： 苏州大学

项目金额： 33万元

中文摘要： 多组分反应具有多步骤"一锅化"完成的特点，因此，发展催化的、高效的多组分反应极为符合发展环境友好化学宗旨下有机合成化学的发展趋势。稀土化合物在催化有机反应方面已有突出的表现，而开发新的、高效的稀土催化剂用于多组分反应已逐渐成为稀土化学和有机合成领域中的一个研究热点。 本项目围绕稀土催化剂应用于多组分反应领域所亟待解决的一些问题而开展，主要致力于设计并合成具有不同电荷和空间效应的配体及其稀土化合物，研究配位环境对稀土化合物催化以亚胺为中间体的多组分有机反应的活性、选择性的影响规律，为设计开发应用于有机多组分反应的新型高效稀土催化体系提供依据和策略，同时发展高效、高选择性有机多组分反应，为合成有实际应用价值的杂环或药物中间体等有机化合物提供方法。

中文关键词： 稀土化合物；有机多组分反应；催化

英文摘要： Multi-component reactions, the multi-step and single operation processes to construct complex molecules, are an important sub-class of tandem reactions. Catalytic and highly efficient multi-component reactions approach closely the requirements of ideal organic synthetic methodologies, which should be environmentally friendly, resource effective and economically favorable. The applications of lanthanide reagents to catalyze organic reactions have made notable progress for recent years. Accordingly, it is of current and growing interest to explore and exploit novel and effective lanthanide catalysts used in multi-component reactions. This project is mainly focused on some problems awaiting solutions in the area of lanthanide catalyzed multi-component reactions. First, we will design and synthesize some ligands with different electronic or steric effects and the corresponding lanthanide compounds with such ligands. Then, we will investigate the effect of coordination spheres of lanthanide centers on the activity and selectivity of lanthanide catalyzed multi-component reactions that using imines as intermediates. The regularity obtained will provide basis and strategies for further optimization of the lanthanide catalysts. Additionally, some efforts will focus, at the same time, on the development of novel multi-component procedures with high activity and selectivity for the generation of libraries of heterocyclic compounds and drug intermediates.

英文关键词： lanthanide compound; organic multi-component reaction; catalysis