Asperger综合症情绪认知的神经心理调控机制研究

项目名称： Asperger综合症情绪认知的神经心理调控机制研究

项目编号： No.30872130

项目类型： 面上项目

立项/批准年度： 2009

项目学科： 金属学与金属工艺

项目作者： 静进

作者单位： 中山大学

项目金额： 33万元

中文摘要： Asperger综合征（AS）的情绪认知脑机制是近年来孤独症认知神经科学研究的热点，本研究以标化的面孔情绪图为刺激标靶，以神经心理测验及脑功能影像学研究为主要手段，采取自行设计的级联是测试法对AS的表情认知上的知觉加工过程，对AS组和正常对照的神经心理反应机制及脑血流变化进行研究。建立了系统的情绪认知测试体系，运用投射测验、神经影像学、人机对话情绪识别任务等对AS儿童的情绪反应、情绪识别及认知反应特征进行比较研究，并用于探索早期ASD患儿的情绪反应及可能的发病机制，阐明了：（1）AS儿童在情绪智力方面有别于正常对照组儿童，表现为具有正常范围的认知水平,但存在明显的执行功能障碍,表现为认知灵活性、工作记忆以及短时记忆等能力相对偏低，情绪认知方式以场依存式为主，行为问题较为突出；（2）AS儿童表情识别能力存在缺陷，与正常儿童模式相似，但识别功效低下；（3）AS 男童控制外源性眼动行为的神经环路具有正常或接近正常的功能，而眼动抑制能力( 注视和眼跳的内源性成分) 存在缺陷；（4）ASD患儿早期即存在对表情认知的能力缺陷；（5）影像学的研究发现AS儿童存在多个脑区的静息态血流灌注水平改变。

中文关键词： Asperger Syndrome;情绪认知;神经心理

英文摘要： The brain mechanism of the emotion cognitive in Asperger syndrome (AS) is the hot spot in autism cognitive neuroscience research in recent years,the present study employ the standardized faces emotional figures as stimulate targets,use neuropsychological tests, brain imaging methods and take the self-developed cascade test to study consciousness processing of expression cognitive in AS , the mechanism of neural psychological reaction and brain blood flow change in both AS and typical children.We established the test system of emotion recognition, use the projection test, nerural imaging,and the man-machine dialogue emotional recognition task to study the emotional response, the emotional recognition and the cognitive reaction characteristics in AS, we found （1）Children with AS performed different with normal children in emotional intelligence. They had normal cognitive capability, however their executive function presented significant defect. Specifically, their cognitive flexibility, working memory and short-term memory presented worse and behavior problem more evident. Their emotional cognition is mainly field independent. （2）AS children had worse facial expression recognition efficacy with normal children though their cognitive model is similar with normal. （3）the neuro circuit to control exogenous eyes movement behavior is normal or next to normal in boys with AS, but the eye movement inhibitory ability(Endogenous composition of gaze and saccade) is defect. （4）ASD have the disabilities of expression cognitive in early age; （5）children with AS have the change of the resting blood perfusion level in multiple brain regions in imaging study

英文关键词： Asperger Syndrome; emotional cognition;neuropsychology