倍半硅氧烷季铵盐型硅橡胶的可控制备及抗菌机理研究

项目名称： 倍半硅氧烷季铵盐型硅橡胶的可控制备及抗菌机理研究

项目编号： No.51463009

项目类型： 地区科学基金项目

立项/批准年度： 2015

项目学科： 一般工业技术

项目作者： 孙复钱

作者单位： 江西省科学院

项目金额： 48万元

中文摘要： 研究具有抗菌功能的硅橡胶材料在生物医学材料领域具有一定的科学意义和良好的应用前景。本课题以γ-(2,3-环氧丙氧)丙基三甲氧基硅烷为原料经过水解，环氧开环加成，季铵盐化反应合成分子结构可控带有环氧活性基团的倍半硅氧烷季铵盐，将倍半硅氧烷季铵盐与硅氧烷低聚物和交联剂、阳离子光引发剂混合组成光固化体系，研究制备倍半硅氧烷季铵盐型硅橡胶抗菌材料。分析倍半硅氧烷季铵盐分子结构和含量以及制备工艺对硅橡胶材料微观结构、热稳定性、力学性能和抗菌性能的影响。探索倍半硅氧烷季铵盐对硅橡胶材料的增强机理，研究细菌与硅橡胶材料表面的相互作用机制以及影响因素，探索倍半硅氧烷季铵盐型硅橡胶抗菌机理。评价并分析硅橡胶材料的抗菌持久性，研究材料长期抗菌过程中表面抗菌基团含量和分布变化规律，探索硅橡胶材料长效抗菌机制。评价硅橡胶材料的体外生物相容性。课题研究为硅橡胶抗菌材料在生物医学领域的应用奠定良好的理论和技术基础。

中文关键词： 倍半硅氧烷；抗菌；硅橡胶；改性；生物医用

英文摘要： Investigation about silicone rubber with antibacterial function have much scientific signification and good application prospect in the field of biomedical materials。In the present investigation, quaternary ammonium functionalized epoxy polyhedral oligomeric silsequioxane with controllable molecular structure are synthesized using γ-(2,3-epoxypropoxy) propytrimethosysilane by a sequential reactions including hydrolysis,epoxy ring opening addition and quaternization. Silicone rubbers with antibacterial activities are prepared by UV induced polymerization of quaternary ammonium functionalized polyhedral oligomeric silsequioxane and siloxane oligomer and crosslinker in the presence of cationic photoinitiator. The microstructure and properties of the anti-bacterial silicone rubbers including thermal stability, mechanical properties, antibacterial properties affected by the content and molecular structure of quaternary ammonium functionalized polyhedral oligomeric silsequioxane as well as preparation process are investigated. Reinforced mechanism of the silicone rubbers is explored. The influence factor and interaction between bacteria and silicone surface are investigated and antibacterial mechanism of the silicone rubbers is explored. Antibacterial endurance of the silicone rubber is evaluated and analysized.Varieties of content and distribution of antibicaterial groups on the surface of silicone rubber are investigated during the long time antibacterial process. Long acting antibiotic mechanism of silicone rubber materials is particularly explored. Vivo biocompatibility of the antibacterial silicone rubber is preliminary valued. The project will provide a basis for the development of antibacterial silicone rubbers with the biomedical applications.

英文关键词： polyhedral oligomeric silsesquioxane;antibacterial;silicone rubber;modification;biomedical