基于脂质组学对大气细颗粒物暴露引发脂质代谢异常和慢性阻塞性肺疾病的相关性研究

项目名称： 基于脂质组学对大气细颗粒物暴露引发脂质代谢异常和慢性阻塞性肺疾病的相关性研究

项目编号： No.91543105

项目类型： 重大研究计划

立项/批准年度： 2016

项目学科： 化学工业

项目作者： 罗茜

作者单位： 中国科学院深圳先进技术研究院

项目金额： 80万元

中文摘要： 大量的流行病学数据表明大气细颗粒物（PM2.5）与心肺疾病及肿瘤的发生和死亡存在关联，其机体损伤、致毒机制和影响过程仍然未有定论并存在争议。慢性阻塞性肺病（慢阻肺，COPD）是一种常见的破坏性肺病，发病率与国内大气环境的污染状况密切相关。COPD患者的炎症反应并不局限于肺部；炎症因子作用在全身的血管系统中，引发血管内皮系统中脂质改变，加剧心肺疾病诱发癌症。本项目基于PM2.5 影响COPD患者心肺功能损伤和炎症反应过程中脂质代谢异常的现象，选取我国九大霾区中广东地区为研究区域，针对典型暴露人群，利用功能脂质组学分析方法，初步开展PM2.5暴露引发心肺功能异常和疾病的相关性分析，探讨脂质代谢异常对COPD心肺功能的影响过程；根据大气污染的暴露剂量、时间和有毒污染物种类和浓度，队列分析PM2.5暴露污染引发心肺功能异常；拟利用功能和炎症脂质组学的生物标志物来研究与PM2.5暴露相关的健康影响。

中文关键词： 细颗粒物；脂质组学；脂质代谢；质谱分析；有毒污染物

英文摘要： Exposure to high levels of fine particulate matter (PM2.5) may trigger cardiopulmonary disease and cancer, but this association remains unclear. Epidemiological researches indicate the function damage, toxicity mechanism and health effect are still controversial and reach inconsistent conclusions. Chronic Obstructive Pulmonary Disease (COPD) is a disease that affects millions worldwide associated with a high disease burden and mortality rate. The rising incidence is not only associated with smoking, but also closely with atmospheric pollution (PM2.5). COPD inflammatory effects occur in the lungs initially, and then on the vascular system, and will change lipid profile. The possible results are aggravated cardiopulmonary disease and induced cancer. COPD patients in the South China region, which isone of the nine largest haze regions, are selected as typical exposed population in this study. Based on abnormal lipid metabolism by PM2.5 affect cardiopulmonary function , this project applied functional lipidomics analysis method to obtain the relationship of PM2.5 exposure and cardiopulmonary dysfunctions and possibly inflammatory factors. According to atmospheric pollution and toxic pollutants exposure dose and time, we will understand the mechanism of lipid metabolism influence on heart and lung function in COPD patients. Using cohort meta-analysis results from PM2.5 pollution exposure-caused cardiopulmonary dysfunction, we will obtain the functional lipidomics biomarkers to investigate the health effects of exposure to PM 2.5 and related organic contaminants.

英文关键词： Fine Particulate Matter;Lipidomics;Lipid Metabolism;Mass Spectrometry Analysis;Toxic Pollutants