三维纳米结构羟基磷灰石用于癌症特征物质快速传感机理研究

项目名称： 三维纳米结构羟基磷灰石用于癌症特征物质快速传感机理研究

项目编号： No.51272289

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 一般工业技术

项目作者： 刘咏

作者单位： 中南大学

项目金额： 80万元

中文摘要： 羟基磷灰石（HAp）由于其特殊的晶体结构已广泛应用于生物大分子吸附、环境检测和净化工程，其在临床上对于肺癌特殊气体的吸附也具有潜在的应用价值。HAp的气体吸附能力与其形貌和结构密切相关。本课题在自主开发的阳离子交换膜辅助电化学沉积技术的基础上，针对材料对早期肺癌特征气体传感作用，重点研究电场条件下HAp 晶体在阳离子交换膜上的形核和晶体长大行为；三维纳米结构HAp的自组装机制；肺癌特征气体在三维纳米结构HAp表面的吸附机制；同时研究HAp与气体分子结合后形貌、晶格常数和化学键等变化，以及电学响应机制和色谱特性，确定其对不同特征气体的传感机制。通过上述研究，建立阳离子交换膜对阴极沉积三维纳米结构HAp的作用机制；获得HAp对于肺癌特征气体的传感规律；形成三维纳米结构HAp快速检测肺癌特征气体、用于肺癌早期诊断的技术原型。

中文关键词： 羟基磷灰石；纳米结构；气敏性能；复合材料；仿生合成

英文摘要： Hydroxyapatite (HAp) has been widely used in the adsorbtion of biomacromolecules, environmental monitoring and purification engineering. It also has the clinical potential in the adsorbtion of characteristic gases of lung cancer. The adsorbing capability is closely related to its morphologies and microstructures.This project is focused on the nucleation and growth of HAp crystals on the cation-exchange membrane in electric field, based on the technique of membrane-assisted electrochemical deposition, which is aimed to develop a novel way for the early diagnosis of lung cancer. The self-assembly mechanism of three-dimentional nanostructure, the adsorbing mechanism of characteristic gases on the surfaces of HAp, the variation of morphologies, crystallographic lattice constants, chemical bonds, electrical responds, as well as chromatographic behavior will be studied in detail, in order to determine the sensing principles for different gases. Through the researches mentioned above, the influences of cathion-exchange membrane on the three-dimentional nanostructured HAp by cathodic deposition will be identified. The transducting mechanism of HAp towards characteristic gases will be obtained. Additionally, a prototype of three-dimentional nanostructured HAp applicable for the rapid detection of characteristic gases and

英文关键词： Hydroxyapatite；nanostructure；gas sensibility；composite；biomimic synthesis