自适应光学在人眼微视野缺损评价中的应用研究

项目名称： 自适应光学在人眼微视野缺损评价中的应用研究

项目编号： No.60808031

项目类型： 青年科学基金项目

立项/批准年度： 2009

项目学科： 轻工业、手工业

项目作者： 戴云

作者单位： 中国科学院光电技术研究所

项目金额： 24万元

中文摘要： 现有视野检查由于刺激视标存在"刺激冗余"，从而难以发现由早期青光眼、视神经萎缩等疾病引起的细微视野缺损。课题研制建立了一套人眼自适应光学微视野检查实验装置，通过自适应光学技术实时校正人眼像差，结合微小刺激视标以大大降低刺激冗余度。编写了符合心理物理学测试的微视野光差灵敏度阈值及视觉频率曲线测量软件，通过特殊的视频转换电路实现了刺激强度的精细调整。与医院联合，实验中分别测量了正常人眼和锥细胞营养不良患者在人眼像差校正前后的光差灵敏度阈值和视觉频率曲线，实验结果发现：校正人眼像差大大降低了刺激视标在眼底视网膜上的弥散程度，降低了视野检查的"刺激冗余"，实验中表现为光差灵敏度阈值的降低及视觉频率曲线的左移，其变化程度与人眼像差大小存在相关性。锥细胞营养不良患者光差灵敏度阈值较正常人眼高，视觉频率曲线较正常人眼右移，自适应光学微视野检查对该类患者有差异性表现，有望应用于临床该类疾病的早期筛查。

中文关键词： 微视野；刺激冗余；自适应光学；早期诊断

英文摘要： It is difficult to make an early dignosis of insult to the visual field made by early glaucoma and optic nerve degeneration because of the redundancy of stimulus used at present. An adaptive optics microperimetry experimental system is developed, combining real time ocluar aberrations correction and micro stimulus,the stimulus redundacy is greatly reduced. A special circuit is used for subtle adjustment of stimulus luminance and the threshold of differential light sensitivity (TODLS)and the frequecy - of - seeing curve (FOSC) are measured by universal perimetry method. Cooperation with hospital, TODLS and FOSC of normal eyes and cone dystrophy eye are measured. The experimental results indicate that ocular aberrations correction can greatly reduce the dispersed degree of stimulus so that the TODLS are depressed and the FOSC move towards the left. The extent of change is correlated with ocular aberration magnitude. The TODLS of cone dystrophy eye are greater than that of normal eyes and the FOSC is on the right of normal eyes', the difference of TODLS and FOSC between the two kinds of eyes makes adaptive optics microperimetry potential for early dignosis of cone dystrophy and other disease such as glaucoma and so on.

英文关键词： Microperimetry; Stimulus redundancy; Adaptive optics; Early diagnosis