类维生素A及其衍生物分子低频振动的太赫兹与低频拉曼光谱研究

项目名称： 类维生素A及其衍生物分子低频振动的太赫兹与低频拉曼光谱研究

项目编号： No.11204190

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 物理学I

项目作者： 左剑

作者单位： 首都师范大学

项目金额： 25万元

中文摘要： 视黄醛、视黄醇、视黄酸等类维生素A及其衍生物分子的低频振动在生物感光体系中发挥了生色团的重要功能。目前只开展了全反式视黄醛分子的太赫兹光谱研究，但是研究中存在如下问题：光谱探测手段单一化；对类维生素A体系中所有分子低频振动的系统比较方法、分析方法都缺乏。这极大限制了对该类生物分子低频振动信息的完整获取和它的电磁、光学性质的深入认识。针对上述问题，本项目拟采用太赫兹与低频拉曼结合的手段研究类维生素A及其衍生物分子的低频振动特性：包括分子的低频振动光谱获得、归属和分子间或分子内相互作用确定，温度、分子官能团或基团变化对低频振动的影响，以及分子的复介电函数性质、约化吸收截面、低频振动模的定域化特点等电磁、光学性质的研究。这些研究能显示出生物分子在与太赫兹光场发生耦合作用时其分子振动偶极矩发生的变化。本项目研究成果可为感光体系中类维生素A分子与蛋白质、氨基酸的结合研究、光致异构化的研究奠定基础。

中文关键词： 太赫兹光谱；类维生素 A分子；吸收线性函数；主成分分析；低频振动

英文摘要： The low-frequency vibrations of the retinoids, which include the retinal, the retinol and the retinoic acid, play an important role of the chromophore in the biological photosensitive systems. Nevertheless, the researches have only focused on the terahertz spectrum of all-trans retinal molecule. Therefore, there are two problems: one is that other spectroscopic methods are absent; the other is that there are not enough systematical analyses of the low-frequency vibrations of all of the retinoid molecules. Then, the research of the low-frequency vibrations and the knowledge of the optical properties and the electromagnetic properties are greatly limited. Here, we will make new researches of the low-frequency vibrations of the retinoids and their derivatives by both terahertz spectrum and low-frequency Raman spectrum. The fruitful areas of optical and electromagnetic researches are listed as follows: the assignment of the spectrum of the low-frequency vibrations, the intramolecular and intermolecular interactions, the influence of the changes of the temperature or the function groups on the low-frequency vibrations, the complex dielectric functions, the reduced absorption cross-section and the localization of low-frequency vibrations. Moreover, the principles of the changes of molecular dipole moments could be

英文关键词： terahertz；retinoids；absorption linear function；Principal component analysis；low-frequency vibration