多肽树枝化聚合物水凝胶

项目名称： 多肽树枝化聚合物水凝胶

项目编号： No.21204047

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 高分子科学

项目作者： 旷桂超

作者单位： 中南大学

项目金额： 25万元

中文摘要： 水凝胶作为一种重要的生物材料，已经在食品工业、组织工程以及生物医药等领域有着广泛的应用。目前，以氨基酸为结构单元的小分子水凝胶机械强度普遍不高，以树枝化聚合物作为凝胶因子的报道极少。多肽树枝化聚合物水凝胶既克服了小分子凝胶力学强度较差的弱点，又同时保留了多肽分子生物相容性好的优点，具有极大的优越性。基于申请人在树枝状分子方向的基础以及所在课题组在树枝化聚合物领域的积累，本课题拟在基金委的资助下，合成不同拓扑结构的多肽树枝化聚合物，构筑一类新型智能化高模量水凝胶。通过比较不同代数的树枝化基元，改变分子内外层结构及端基，加入共价或非共价交联的第二组分，引入响应性基团，系统研究水凝胶的形貌，力学强度以及刺激响应性质等,探索结构与性质之间的规律。期望本项目的实施能拓展树枝化聚合物和水凝胶两个方向，并在新材料领域体现出更多基础研究价值。

中文关键词： 树枝化聚合物；水凝胶；氨基酸；氟硼染料；温敏性

英文摘要： As one kind of important biological materials,hydrogels have shown wide application in the fields of food, tissue engineering and biological medicine and so on. At present, most of the low molecular weight hydrogels based on amino acids show poor mechanical strength. Furthermore, there are few reports referring to gelators from dendronized polymers. Hydrogels based on peptidic dendronized polymers will not only exhibit better mechanical properties than that of low molecular weight gels, but also display good biocompatibility. According to applicant strong background in dendrimers and our group excellent work in dendronized polymers, in this grant application, we propose strategies to develope a series of peptidic dendronized polymers with different types of architectures by changing dendritic generations, branches and peripheral groups. We aim to get novel kind of smart and high mechanical strength hydrogels by adding the second components or introducing functional chromographies. Therefore,we can perform a systemic studies on their morphology, mechanical properties and responsibility. Hopefully, the practise of this proposal will enlarge the research boundary of both dendronized polymers and hydrogels, and show their importance in the fundanmental studies of new materials as well.

英文关键词： dendronized polymers；hydrogel；amino acid；BODIPY；thermoresponsibility