脑活动的低频振荡与持续注意之功能磁共振研究

项目名称： 脑活动的低频振荡与持续注意之功能磁共振研究

项目编号： No.31471084

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 神经、认识与心理学

项目作者： 臧玉峰

作者单位： 杭州师范大学

项目金额： 90万元

中文摘要： 反应时的变异增大是持续注意力减低的一个重要指标。最近研究发现，反应时的变异主要在低频（0.05Hz左右）段，而这个低频段与静息态fMRI的低频振荡有重叠，但相关研究还比较少，并且传统的Go-NoGo或者Flanker等任务，在分析反应时的变异时，因为任务的切换、任务呈现频率过低等原因，不利于频率的深入分析。本项目拟采用近年开发的一种新的持续注意实验范式，即要求被试连续轻按压力传感器，探讨手指压力的低频振荡与传统实验范式的反应时变异的关系、与静息态fMRI低频振荡的关系，以及与持续注意任务fMRI脑活动的关系，并探索这种新的实验范式的在注意缺陷多动障碍的应用研究，并从新的角度探讨持续注意的脑机制。

中文关键词： 功能磁共振成像；脑网络；反应时变异；持续注意；脑自发活动

英文摘要： Increased intraindividual variability of reaction time (RT-IIV) is a major feature of decreased sustained attention. Recently, it was found that the RT-IIV is dominantly in low frequency (with a peak at about 0.05 Hz). And this low frequency fluctuation (LFF) of RT-IIV is largely overlapped with the LFF of resting-state BOLD signal. However, few studies have investigated the correlation between the BOLD LFF and RT-IIV LFF. Conventioonal sustained attention tasks, e.g., Go-NoGo or Eriksen Flanker task, usually have two or more tasks. Subjects has to shift their mental state between these tasks. Such shift will make the frequency analysis complicated. And only low frequency (effective sampling rate usually < 0.25 Hz if ISI = 2s) can be obtained. This applicant has proposed a new paradigm for sustained attention, namely continuous finger force. The current application will compare the LFF in continuous finger force with RT-IIV of conventional Go-NoGo and Eriksen Flanker tasks, with resting-state BOLD LFF, and task fMRI activities. We also will apply this new paradigm to attention deificity hyperactivity disorder. The above studies will help further understand the mechanism of sustained attention.

英文关键词： fMRI;brain network;reaction time variability;sustained attention;spontaneous brai activity