微弧氧化镁表面预钙化纳米生物涂层的特性调控及其降解行为

项目名称： 微弧氧化镁表面预钙化纳米生物涂层的特性调控及其降解行为

项目编号： No.51272055

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 一般工业技术

项目作者： 胡津

作者单位： 哈尔滨工业大学

项目金额： 80万元

中文摘要： 本项目以微弧氧化镁为研究对象，提出获得具有高生物活性及低降解速率生物医用镁表面改性设计的新思路。通过在微弧氧化镁表面化学构建预钙化纳米生物涂层，实现对微弧氧化镁表面状态的调整与控制；深入系统地研究微弧氧化镁表面预钙化涂层的微观组织结构，了解和掌握不同种类预钙化涂层在微弧氧化镁表面的形成条件，揭示Mg2+在钙化涂层形核与生长过程中的作用本质。研究经预钙化处理的微弧氧化镁在模拟体液中的组织演化与降解规律，并揭示其在模拟体液中发生腐蚀降解的条件及影响因素，建立涂层微观组织结构与腐蚀性能之间的内在联系，阐明预钙化涂层在模拟体液中对诱导羟基磷灰石膜生长的贡献及对微弧氧化镁的腐蚀抑制作用。为新型生物医用镁及其合金表面改性体系的开发提供设计思路和理论依据。

中文关键词： 微弧氧化镁；涂层；形成机制；腐蚀行为；生物相容性

英文摘要： The substrate material was micro-arc oxidized magnesium, a new idea to improve the biocompatibility and decrease the corrosion rate of the magnesium surface was advanced. A pre-calcified coating was prepared on the surface of micro-arc oxidized magnesium by a simple chemical method, and the surface states of the micro-arc oxidized magnesium could be controlled. The microstructure evolution of the pre-calcified specimens befor and after soaking in simulated body ?uid (SBF) was characterized. By understanding the relationship between the microstructure and the fabrication conditions of the pre-calcified coating to investigate the formation mechanism of the coating. By investigating the formation conditions of the pre-calcified coating on the surface of the micro-arc oxidized magnesium to clarify the functionary essence of Mg2+ during the formation and growth of the calcified coating. The corrosion behavior of the substrate and the pre-calcified samples in SBF were also investigated. The contribution of the pre-calcified coating on the growth of biomimetic hydroxyapatite （HA） and the restrainability of the corrosion on the substrate was illustrated in the SBF solution.

英文关键词： micro-arc oxidized magnesium；coating；formation mechanism；corrosion behvior；biocompatibility