强迫症及其同胞左右半球功能偏侧化脑机制研究

项目名称： 强迫症及其同胞左右半球功能偏侧化脑机制研究

项目编号： No.81201049

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 神经系统疾病、精神疾病

项目作者： 彭子文

作者单位： 华南师范大学

项目金额： 23万元

中文摘要： 强迫症（OCD）左右半球功能偏侧化机制是研究其脑机制的前提和基础。OCD患者左右半球分工模式存在异常，但是，OCD患者在静息状态下左半球和右半球的活动模式，迄今还不清楚。另外，OCD患者这种特征性的左右半球活动模式是一种"特质"还是一种"状态"，也尚未知晓。研究发现OCD患者在静息状态下的默认网络存在异常，且主要表现为左半球功能增强，这提示OCD患者在静息状态下左右半球的活动模式存在异常。为此，我们推测OCD患者在静息状态下左右半球功能存在偏差化异常，另外，OCD患者的未患病同胞较正常人群具有更多患强迫症的素质，因此，我们推测未患病同胞可能存在相似的偏侧化异常。为证实这一假说，我们拟利用静息态fMRI采集脑神经元的活动信息，运用基于体素的镜像同伦功能连接方法分析静息状态下左半球和右半球的活动特征。本课题将从新的视角阐述OCD患者静息状态下左右脑偏侧化机制，为OCD的防治提供新的生物学标记。

中文关键词： 强迫症；静息态；功能性磁共振成像；偏侧化；

英文摘要： Patients with Obsessive-Compulsive Disorder (OCD) are associated with the hemispheric lateralization abnormalities, which is the foundation for studying OCD brain mechanism. Despite some recent work on neuroimaging studies, very little is still known about the functional activities at rest, i.e., resting state, in this clinical group. In particular, whether such an abnormality characteristic is a "trait" or a "state" is not yet fully unknown. Most recent studies have suggested that there were abnormal default mode networks (DMN) in OCD patients during resting-state and major abnormalities were increasing activities on the left hemisphere, which suggested that there is abnormal activities between left hemisphere and right hemisphere during resting-state in this clinical group. The current study aims to examine the resting-state of patients with OCD and their unaffected siblings. Moreover, it will focus on the mechanism of hemispheric lateralization in patients with OCD patients and attempt to identify any potential biological marker for the prevention and treatment of OCD. Based on the existing findings from the literature, we expect both patients OCD and their unaffected siblings will show a hemispheric lateralization during resting-state.

英文关键词： Obsessive-Compulsive Disorder；resting-state；fMRI；lateralization；