CO2诱导纳米乳液介质内中药纳米结构脂质载体的绿色组装、微结构调控与构效关系

项目名称： CO2诱导纳米乳液介质内中药纳米结构脂质载体的绿色组装、微结构调控与构效关系

项目编号： No.21276160

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 化学工业

项目作者： 文震

作者单位： 深圳大学

项目金额： 78万元

中文摘要： 纳米结构脂质载体 (Nanostructured Lipid Carriers, NLCs)可提高难溶中药成分生物利用度，并具有缓释作用，是一种新型中药传递系统。以固/液混合脂质为载体，白术内酯为模型中药，以超临界/压缩CO2诱导的纳米乳为软模板，为载药NLCs的绿色可控组装，实现微结构精细调控提供了一条新途径。采用超临界在线实验表征与DPD介观模拟结合的方法，研究载药NLCs动态微结构与组装动力学过程, 阐释组装过程调控载药NLCs微结构机制。获取载药NLCs产品静态结构信息，构筑NLCs的动态与静态结构相结合的多层次微结构信息，研究微结构与载药NLCs的载药性能、药物释放性能、稳定性、生物利用度、体外生物活性等药学效能之间的构效关系。按化学产品工程理念，揭示CO2诱导纳米乳介质中载药NLCs组装行为、结构与药学效能的关系规律，为复杂流体作用下胶体多相体系构建纳米脂质载体提供理论支撑。

中文关键词： 纳米结构脂质载体；超临界/压缩 CO2；纳米乳；微结构；构效关系

英文摘要： As a novel drug delivery system, nanostructured lipid carriers (NLCs) can improve the bioavailability and achieve sustained-releasing for lipophilic or poorly soluble compounds purified from Chinese traditional medicine. With solid/liquid mixing lipids as the carriers, butenolides as model drugs, the nanostructured lipid carriers loading drugs were assembled in the nanoemulsions induced by supercritical/compressed CO2 used as soft templates, providing a novel approach for microstructure control of nanostructured lipid carriers loading drugs with a green technology. Combining the measurement on line and mesoscale simulation with dissipative particle dynamics simulation, the dynamical microstructures and self-assembly process of NLCs loading drugs were studied, so as to illuminate the mechanism of microstructure control by modifying the procedure parameters of the soft templates. The multi-layer microstructure system was construed by combination of the dynamical microstructures and static microstructures. The relationships of microstructure and pharmaceutical activities including the drug loading efficiency, release property, stability, bioavailability, and the anti-tumor effects in vitro were summarized. According to the key ideas of product engineering, the evolution of self-assembly behaviour, microstructures a

英文关键词： nanostructured lipid carriers；Supsupercritical/compressed CO2；nanoemulsions；microstructures；structure-function relationship