AuNPs-PDMS复合微薄膜电导式表面应力生物传感器制备及力电传感机理研究

项目名称： AuNPs-PDMS复合微薄膜电导式表面应力生物传感器制备及力电传感机理研究

项目编号： No.61471255

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 无线电电子学、电信技术

项目作者： 桑胜波

作者单位： 太原理工大学

项目金额： 83万元

中文摘要： 表面应力生物传感器从分子量级对分析物进行探测分析，传感检测精度更高；AuNPs-PDMS复合微薄膜具有良好的生物相容性和宏观量子隧道效应，其灵敏度比传统传感材料高出大约两个数量级；电导式信号检测利于MEMS 生物传感芯片集成。本项目拟开展AuNPs-PDMS复合微薄膜电导式表面应力生物传感器制备方法、(表面应力)力电传感机理等关键科学问题研究；解决高灵敏度AuNPs-PDMS复合微薄膜的设计与加工制备，突破AuNPs-PDMS工艺与传统工艺相结合的难题；建立AuNPs-PDMS复合微薄膜力电信号的电导式检测方法和集成工艺；针对肾病综合症引起的尿中蛋白质升高进行检测，验证AuNPs-PDMS复合微薄膜电导式表面应力生物传感器的力电传感高灵敏度特性，为实现高灵敏度生物信号的集成探测提供支持。

中文关键词： AuNPs-PDMS复合微薄膜；表面应力；力电传感机理；生物传感器；集成

英文摘要： Surface stress-based biosensor uses a balance of free energy change induced by the binding reaction to measure the analytes, which has higher precision. Gold Nanoparticles-Polydimethylsiloxane (AuNPs-PDMS) composite micromembrane has the characteristic of good biocompatibility and macro quanta tunnel effect, the sensitivity is about two orders of magnitude higher than the traditional metal or semiconductor piezoresistive material. Conductive signal detection is easy to BioMEMS integration. The key scientific problems, such as the electromechanical sensing mechanism and the fabrication process will be researched. The goal of the project is to design and fabricate the high sensitive AuNPs-PDMS composite micromembrane and biosensor, to build the conductive detection and integration process of the electromechanical signal of AuNPs-PDMS composite micromembrane. Last the functionalization will be designed and researched to detect the elevation of urine protein induced by the hydremic nephritis for proving and realizing the electromechanical sensing mechanism. This research will provide the technical and theoretical support for the realization of high sensitive integrated detection of biological signals.

英文关键词： AuNPs-PDMS composite micromembrane;Surface stress;electromechanical sensing mechanism;Biosensor;Integration