冠状动脉内药物洗脱支架药物缓释的血流动力学实验与数值研究

项目名称： 冠状动脉内药物洗脱支架药物缓释的血流动力学实验与数值研究

项目编号： No.10872138

项目类型： 面上项目

立项/批准年度： 2009

项目学科： 能源与动力工程

项目作者： 蒋文涛

作者单位： 四川大学

项目金额： 40万元

中文摘要： 药物缓释规律是药物洗脱支架研究的重要内容之一，血流动力学体外实验和数值仿真是研究药物洗脱支架药物缓释规律的必要手段。本项目针对药物释放率、不同支架结构（截面的高宽比、不同支架连接筋等）、考虑血管的斑块属性和跨壁传质特性等，研究了冠状动脉内的血流动力学和药物浓度分布规律，结果显示支架结构及其表面药物释放率对血管内的血流动力学和药物浓度的分布规律具有重要影响，具体结论可为药物洗脱支架在涂层设计、药物缓释曲线设计，延长药物缓释时间、构型设计等方面提供理论依据和指导性建议。同时，为验证数值计算的合理性，研制了一套"药物洗脱支架体外流场PIV测试系统"及其测试方法，为药物洗脱支架的体外实验和评价提供一种新的、有效的实验手段。另外，本项目还探索性的研究了药物缓释的体外测试技术，以及支架随心脏波动的实时图像处理技术和流固耦合数值分析等，对今后药物洗脱支架的深入研究具有指导意义。

中文关键词： 药物洗脱支架；血流动力学；浓度场；药物缓释

英文摘要： The law of drug delivery is an important part of drug-eluting stent research. Hemodynamic in vitro experiments and numerical simulations are the necessary means to study the law. According to the terms of the drug release rate, the different stent structure (such as height-width ratio of the cross-section, different DES's link, etc.), considering the properties of vascular plaque and transmural mass transfer characteristics, this project studied the intra coronary hemodynamics and the law of drug concentration distribution. The results showed that the stent structure and its surface drug release rate have an important impact on intravascular hemodynamics and drug concentration distribution. The specific conclusions could provide a theoretical basis and guidance suggestions for the DES's coating design, drug delivery curve design, extension of drug releasetime, configuration design and other aspects. Furthermore, a set of "DES in vitro flow field PIV test system" and test methods was developed to verify the rationality of numerical calculation, which provided a new effective experimental means for DES in vitro experiments and evaluation. In addition, this project exploringly studied the in vitro testing technology of drug delivery, as well as the real-time image processing technology of stents with heart fluctuations and numerical analysis of fluid-structure interaction. These have guiding significance for the future in-depth research of DES.

英文关键词： drug-eluting stent；hemodynamic; drug concentration distribution; drug delivery