适用于抗肿瘤药物载体的含介孔结构的多重响应复合微球

项目名称： 适用于抗肿瘤药物载体的含介孔结构的多重响应复合微球

项目编号： No.51273047

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 一般工业技术

项目作者： 杨武利

作者单位： 复旦大学

项目金额： 80万元

中文摘要： 纳米粒子载药系统具有独特的优势，容易到达各个部位，甚至可以穿透血脑屏障；近来发现特定尺度(50-200nm)的纳米粒子对肿瘤组织具有增强渗透与停留效应(EPR)，从而对肿瘤组织具有一定的被动靶向作用。由于肿瘤部位的一些物理化学性质与正常组织不同，也可利用这些性质实现对肿瘤部位的主动靶向给药。环境响应纳米粒子(微球)由于其物理化学性质及胶体性质可随环境改变(如温度，pH，氧化还原，光，电场，磁场等)，具有作为药物控释载体的潜力。我们提出系统研究含介孔结构的多重环境响应(pH/热、光/热、还原/热)复合微球在抗肿瘤药物载体方面的应用，研究典型抗肿瘤药物与载体的作用机理，基于介孔结构实现较高的载药率，将介孔作为药物的仓库，环境刺激作为开关，发挥多重响应的协同作用，实现人体温附近药物的可控释放；研究多重响应载药微球对肿瘤细胞的杀伤作用，发展具有应用前景的抗肿瘤纳米粒子载药系统。

中文关键词： 介孔二氧化硅；复合微球；环境响应；药物载体；光热治疗

英文摘要： Nanoparticles used as drug delivery system have unique advantages. Nanoparticles can easily reach specific sites, or even cross blood-brain barrier. Recently, it is found that nanoscale particles (50-200nm) have enhanced permeability and retention (EPR) effect for tumor tissues, which facilitates the delivery of drugs exclusively to the intended tissues with passive targeting effect. The different physicochemical properties between tumor tissues and normal tissues could be exploited as active targeting drug delivery system to tumor region. The environment responsive nanoparticles (microspheres) could change their physicochemical and colloidal properties with external environment change (such as temperature, pH, redox, light, electric field, magnetic field and so on), so they have great potentials to utilized as controlled drug release system. Here we propose a project to invesitigate the multi-responsive (pH/temperature, light/temperature, reduction/temperature) composite microspheres containg mesoporous channels applied as anti-cancer drug delivery system systematically, where the interaction between the anticancer drugs and drug delivery system was also invetigated. Based on the "storehouse" effect of mesoporous channels, high loading capacity could be achieved, and the environment stimuli acts like as a trigg

英文关键词： Mesoporous silica；composite microspheres；environment responsive；drug carriers；photothermal therapy