面向青光眼早期诊断的光学相干弹性成像方法研究

项目名称： 面向青光眼早期诊断的光学相干弹性成像方法研究

项目编号： No.61475143

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 无线电电子学、电信技术

项目作者： 李鹏

作者单位： 浙江大学

项目金额： 80万元

中文摘要： 青光眼是导致人眼失明的三大致盲眼病之一，青光眼引起的视觉功能损伤是不可逆的，后果严重，因此，青光眼的早期诊断、合理治疗对最大限度的保护患者视觉功能至关重要。但是，目前尚缺乏有效的技术能够对青光眼进行早期的检测，通常只能等到后期，在视神经组织发生严重的破坏之后。一般认为小梁网的硬化是原发性开角型青光眼的最主要的诱导因素之一，鉴于此，本项目开展面向早期青光眼诊断的小梁网光学相干弹性成像方法研究。基于光学相干层析术的位相信息发展高灵敏度组织微小运动/变形的检测技术，获取活体组织的弹性信息，实现小梁网组织的高分辨率光学相干弹性成像，并结合房角结构信息开展早期青光眼的成像应用研究，探索青光眼与眼压及房水循环通路受阻间的关联机制。该项目的研究是光学相干层析术的重要功能拓展，将为青光眼病理机制的研究和青光眼的早期诊断提供关键性的技术手段，有望在视神经组织产生永久性的破坏之前发现青光眼并实施早期治疗。

中文关键词： 光学相干弹性成像；青光眼；小梁网；位相信息

英文摘要： Glaucoma is one of the three leading causes of blindness for human.The damage of glaucoma to the visual system is irreversable and serious. Thus, the early detection and effective treatment is vital for preserving patients' vision. However, currently,no method is avilable for early detection of glaucoma, leaving us waiting for the evidence of severe damage to the visula system. The stiffness of trabecular meshwork (TM) has been regarded as the primary source of outflow resistence in the primary open-angle glaucoma. Accordingly, this project aims to develop optical coherence elastography for early detection of glaucoma. Based on the phase information of optical coherence tomography, a high-sensitive method for measuring tiny tissue movement/deformation will be developed.The elastic property of tissue will be obtained in vivo. High-resolution optical coherence elastrography of trabecular meshwork will be realized. With the developed system, the preliminary study of early glaucoma will be performed. The dynamic interaction between the TM and the intraocular pressure will be explored. This project is a important functional extension of the current optical coherence tomography, providing a critical tool for the scientific study of the pathological mechanism and the clinic diagnosis of glaucoma.It provides the possibility of glaucoma diagnosis and treatment guidance, prior to the permanent damange to the visual system.

英文关键词： Optical coherence elastography;Glaucoma;Trabecular meshwork;Phase information