基于等离子体技术的可降解镁基金属表面梯度膜的构建及其抗菌行为研究

项目名称： 基于等离子体技术的可降解镁基金属表面梯度膜的构建及其抗菌行为研究

项目编号： No.51501218

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 一般工业技术

项目作者： 赵颖

作者单位： 中国科学院深圳先进技术研究院

项目金额： 21万元

中文摘要： 镁基金属作为一种新型的可降解医用金属材料，越来越多地引起生物医用材料领域的广泛关注。然而生理条件下的快速降解和由于植入感染带给病人的痛苦，严重限制了其在临床上的广泛应用。本项目提出采用等离子浸没离子注入技术在镁基金属表面设计构建具有良好耐蚀性的表面梯度抗菌膜。前期研究已经证实通过Zr-O等离子注入可以有效提高二元镁合金的耐蚀性和抗菌性能。为了揭示等离子注入镁基金属表面梯度膜的抗菌机理，本课题以纯镁和三元Mg-Zn-Zr合金为基体材料，系统地研究Zr-O等离子注入表面梯度膜的构建，膜结构组成对镁基金属降解速率的影响，以及降解过程中表面梯度膜的结构变化和营造的表面微环境对细菌粘附和活力的影响，并运用大鼠模型追踪改性镁基金属在体内的降解规律和抗菌行为。通过本项目的研究，理解并掌握等离子处理镁基金属的腐蚀降解规律和抑制细菌感染的作用机制，为研究和发展抗细菌感染生物可降解镁基金属材料提供科学依据。

中文关键词： 镁合金；表面改性；生物材料；抗菌性能

英文摘要： Magnesium-based metal, as a new biodegradable metallic material, causes more and more attention in the field of biomedical materials. However, the patients’ suffering brought by the rapid degradation under physiological conditions and implant infections severely limits its widespread application in the clinic. In this project, plasma immersion ion implantation technique is used to design and build a gradient antimicrobial film with good corrosion resistance on magnesium-based metal surface. Previous studies have shown that Zr-O ion implantation has positive impact on improving the antibacterial properties of binary magnesium alloys. In order to reveal antibacterial mechanism of surface gradient film formed by ion implantation, pure magnesium and ternary Mg-Zn-Zr alloy are used as the matrix material in this project. We will systematically research that the preparation of the surface gradient membrane by Zr-O ion implantation and impact of its structure and composition on the degradation rate of magnesium-based metal, the impact of the structural changes of the gradient film and the formed micro-environment on bacterial adhesion and viability during the process of degradation, and the in vivo degradation and antimicrobial behavior of magnesium-based metal by using rat models. The degradation rule of plasma-treated magnesium-based metal and its inhibition mechanism of bacterial infections will be understood and mastered by our study. A scientific basis will be provided in the research and development of biodegradable magnesium-based metal with anti-bacterial infections.

英文关键词： magnesium alloy;surface modification;biomaterials;antibacterial property