新型纳米囊泡的构建并用于癌症诊断和治疗的研究

项目名称： 新型纳米囊泡的构建并用于癌症诊断和治疗的研究

项目编号： No.21502129

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 数理科学和化学

项目作者： 李高参

作者单位： 四川大学

项目金额： 21万元

中文摘要： 囊泡在生物膜仿生、药物和基因传输、无机材料的微反应器以及纳米材料制备等众多领域均得到广泛的应用。现有构筑囊泡的材料普遍存在结构复杂、合成困难以及价格昂贵等缺点，从而极大地限制了囊泡体系的高通量构建和性能筛选。本项目基于目前离子型功能囊泡的研究现状，拟发展氮鎓盐高效绿色的合成新方法，构建鎓盐分子库，为构建功能多样的纳米囊泡体系提供化学基础。同时，利用抗衡离子诱导形成囊泡的策略，制备并筛选尺寸单一、性能优异的纳米囊泡，并深入研究基于抗衡离子诱导的离子型纳米囊泡的构建机制，为今后离子型囊泡的构筑提供强有力的理论基础。此外，基于巧妙的分子设计，赋予目标囊泡体系磁共振显影、荧光成像及药物和基因在肿瘤细胞环境下的智能释放等一系列功能，开发它们在癌症诊断及抗癌药物和基因传输中的应用。

中文关键词： 纳米囊泡；氮杂鎓盐；环境响应；癌症诊断；基因和药物传递

英文摘要： Vesicles have been a hot subject of research because of their applications in a variety of different areas reaching from models of biological membranes, agents for drug/gene delivery, and microreactors for the production of inorganic materials to the preparation of nanomaterials. However, the materials employed for construction of vesicles are usually either not easily available or expensive and require multi-step synthesis, which has greatly impeded the high throughput construction and screening of novel vesicles. Based on the research status of the ionic vesicle, this proposal focuses on development of new strategies for efficient and green synthesis of N-containing onium salts in effort to establish a library of onium salts. Following the strategy of counterion-induced vesicle formation, different types of monodispersed and multifunctional nanovesicles will be obtained on basis of the onium salts library and a deeper understanding of the counterion-induced strategy is expected to be disclosed. Meanwhile, a series of properties including MR and fluorescence imaging and smart delivery of gene and drug are designed for target nanovesicles, which would offer a promising application in the cancer diagnosis and therapy.

英文关键词： nanovesicle;N-containing onium salt;environment responsive;cancer diagnosis;gene and drug delivery